ELL

Gene Symbol	ELL
Entrez Gene	8178
Alt Symbol	C19orf17, ELL1, MEN, PPP1R68
Species	Human
Gene Type	protein-coding
Description	elongation factor RNA polymerase II
Other Description	ELL gene (11-19 lysine-rich leukemia gene)|RNA polymerase II elongation factor ELL|eleven-nineteen lysine-rich leukemia protein|protein phosphatase 1, regulatory subunit 68
Swissprots	P55199
Accessions	AAC28752 EAW84707 EAW84708 P55199 AB208794 BAD92031 AF157562 AAD45322 AK225481 AK293105 BAF85794 AK309878 AL136771 CAB66705 BC010010 BC033673 BC049195 AAH49195 BC064558 BC108256 BI458899 U16282 AAA57120 XM_011528330 XP_011526632 XR_936207 NM_006532 NP_006523
Function	Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. {ECO:0000269|PubMed:16006523, ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:22252557, ECO:0000269|PubMed:23932780, ECO:000
Subcellular Location	Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Colocalizes with EAF2 to nuclear speckles. Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.
Tissue Specificity	Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ELL protein fragment - ab159955 from Abcam Category Protein Source Wheat germ Species Human

ELL / MEN Antibody Blocking Peptide - LS-E86 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ELL / MEN Antibody Blocking Peptide - LS-E10481 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ELL / MEN Antibody Blocking Peptide - LS-E13981 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ELL / MEN Antibody Blocking Peptide - LS-E10154 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ELL Protein - H00008178-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ELL-Antibody-C-term-Blocking-peptide - BP10171b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ELL-Antibody-C-term-Blocking-Peptide - BP9479b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ELL - H00008178-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ELL - H00008178-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ELL fusion protein - ag0617 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

MEN Blocking Peptide - CBP3917 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

ELL (D125) Peptide - BS2020P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human RNA polymerase II elongation factor ELL(ELL) - CSB-YP007608HU CSB-EP007608HU CSB-BP007608HU CSB-MP007608HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ELL Recombinant Protein Antigen - NBP2-13955PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MEN Blocking Peptide - abx162410 from Abbexa Category Peptide Species Human, Mouse, Rat

ELL Peptide, Human - M34GP04863H from Creative Peptides Category Peptide Source Synthetic. Species Human

MEN peptide - orb256804 from Biorbyt Category Peptide Prices $272.00, $519.00 Sizes 1 mg, 5 mg

RNA polymerase II elongation factor ELL (ELL), Recombinant Protein - MBS954307 from MyBioSource Category Protein Prices $1,415.00, $1,415.00, $1,645.00, $1,645.00, $2,390.00, $2,390.00, $2,835.00, $2,835.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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