Gene Symbol | PIGR |
---|---|
Entrez Gene | 5284 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | polymeric immunoglobulin receptor |
Other Description | hepatocellular carcinoma associated protein TB6|hepatocellular carcinoma-associated protein TB6|poly-Ig receptor |
Swissprots | P01833 Q8IZY7 Q68D81 |
Accessions | AAB23176 AAF72193 CAA03384 CAC10060 EAW93515 EAW93516 P01833 AF272149 AAN65630 AK225471 AK310199 AY178835 BC110061 BC110494 AAI10495 BC110495 AAI10496 CR749533 CAH18339 M24559 AAA36102 S62403 AAB20203 X73079 CAA51532 XM_011509629 XP_011507931 NM_002644 NP_002635 |
Function | This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
Top Pathways | Intestinal immune network for IgA production |