Gene Symbol | PIGR |
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Entrez Gene | 5284 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | polymeric immunoglobulin receptor |
Other Description | hepatocellular carcinoma associated protein TB6|hepatocellular carcinoma-associated protein TB6|poly-Ig receptor |
Swissprots | P01833 Q8IZY7 Q68D81 |
Accessions | AAB23176 AAF72193 CAA03384 CAC10060 EAW93515 EAW93516 P01833 AF272149 AAN65630 AK225471 AK310199 AY178835 BC110061 BC110494 AAI10495 BC110495 AAI10496 CR749533 CAH18339 M24559 AAA36102 S62403 AAB20203 X73079 CAA51532 XM_011509629 XP_011507931 NM_002644 NP_002635 |
Function | This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
Top Pathways | Intestinal immune network for IgA production |
SC CRISPR/Cas9 KO Plasmid (h) - sc-402459 from Santa Cruz Biotechnology
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SC HDR Plasmid (h) - sc-402459-HDR from Santa Cruz Biotechnology
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SC Double Nickase Plasmid (h) - sc-402459-NIC from Santa Cruz Biotechnology
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SC Double Nickase Plasmid (h2) - sc-402459-NIC-2 from Santa Cruz Biotechnology
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SC CRISPR Activation Plasmid (h) - sc-402459-ACT from Santa Cruz Biotechnology
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SC CRISPR Activation Plasmid (h2) - sc-402459-ACT-2 from Santa Cruz Biotechnology
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SC Lentiviral Activation Particles (h) - sc-402459-LAC from Santa Cruz Biotechnology
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SC Lentiviral Activation Particles (h2) - sc-402459-LAC-2 from Santa Cruz Biotechnology
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SC siRNA (h) - sc-42964 from Santa Cruz Biotechnology
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SC shRNA Plasmid (h) - sc-42964-SH from Santa Cruz Biotechnology
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SC shRNA (h) Lentiviral Particles - sc-42964-V from Santa Cruz Biotechnology
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pIgR RNAi - H00005284-R01 from Novus Biologicals
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MISSION® esiRNA - EHU072031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16795 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16795 from Sigma-Aldrich
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PIGR siRNA (Human) - CRH3530 from Cohesion Biosciences
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shRNA set against Human PIGR (NM_002644.3) - SHH375504 from Creative biogene
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Human PIGR siRNA - orb264032 from Biorbyt
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PIGR shRNA Plasmid (Human) - CHH3530 from Cohesion Biosciences
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PIGR miRNA 3'UTR clone - MiUTR3H-01787 from Creative biogene
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