| Gene Symbol | COL8A1 |
|---|---|
| Entrez Gene | 1295 |
| Alt Symbol | C3orf7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | collagen, type VIII, alpha 1 |
| Other Description | cell proliferation-inducing protein 41|collagen VIII, alpha-1 polypeptide|collagen alpha-1(VIII) chain|endothelial collagen|smag-64|smooth muscle cell-expressed and macrophage conditioned medium-induced protein smag-64 |
| Swissprots | Q96D07 Q53XI6 P27658 D3DN42 |
| Accessions | EAW79837 EAW79838 EAW79839 EAW79840 P27658 AF170702 AAF89665 AK311449 AL359062 AY550974 AAT52220 BC013581 AAH13581 BG938623 BQ774361 BT009917 AAP88919 CA393523 CB269463 CN484310 DA663372 DQ893873 ABM84799 X57527 CAA40748 NM_001850 NP_001841 NM_020351 NP_065084 |
| Function | Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. {ECO:0000269|PubMed:11708810}. |
| Subcellular Location | Secreted, extracellular space, extracellular matrix, basement membrane. |
| Tissue Specificity | Expressed primarily in the subendothelium of large blood vessels. Also expressed in arterioles and venules in muscle, heart, kidney, spleen, umbilical cord, liver and lung and is also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea and sclera, and in the perichondrium of cartilaginous tissues. In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Also expressed in mast cells, and in astrocytes during the repair process. Expressed in Descemet's membrane. Specifically expressed in peritoneal fibroblasts and mesothelial cells. {ECO:0000269|PubMed:10686422, ECO:0000269|PubMed:2376131, ECO:0000269|PubMed:7734329}. |
COL8A1 CRISPR/Cas9 KO Plasmid (h) - sc-405174 from Santa Cruz Biotechnology
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COL8A1 HDR Plasmid (h) - sc-405174-HDR from Santa Cruz Biotechnology
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COL8A1 Double Nickase Plasmid (h) - sc-405174-NIC from Santa Cruz Biotechnology
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COL8A1 Double Nickase Plasmid (h2) - sc-405174-NIC-2 from Santa Cruz Biotechnology
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COL8A1 CRISPR Activation Plasmid (h) - sc-405174-ACT from Santa Cruz Biotechnology
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COL8A1 CRISPR Activation Plasmid (h2) - sc-405174-ACT-2 from Santa Cruz Biotechnology
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COL8A1 Lentiviral Activation Particles (h) - sc-405174-LAC from Santa Cruz Biotechnology
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COL8A1 Lentiviral Activation Particles (h2) - sc-405174-LAC-2 from Santa Cruz Biotechnology
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COL8A1 siRNA (h) - sc-78026 from Santa Cruz Biotechnology
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COL8A1 shRNA Plasmid (h) - sc-78026-SH from Santa Cruz Biotechnology
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COL8A1 shRNA (h) Lentiviral Particles - sc-78026-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU095971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6404 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6404 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01204 from Sigma-Aldrich
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COL8A1 siRNA (Human) - CRH0909 from Cohesion Biosciences
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COL8A1 - MBS8228905 from MyBioSource
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shRNA set against Human COL8A1 (NM_001850.4) - SHH267449 from Creative biogene
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Human COL8A1 siRNA - orb261411 from Biorbyt
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COL8A1 shRNA Plasmid (Human) - CHH0909 from Cohesion Biosciences
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COL8A1 miRNA 3'UTR clone - MiUTR3H-00480 from Creative biogene
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COL8A1 miRNA 3'UTR clone - MiUTR3H-00481 from Creative biogene
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