| Gene Symbol |
PCSK2
|
| Entrez Gene |
5126
|
| Alt Symbol |
NEC 2, NEC-2, NEC2, PC2, SPC2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proprotein convertase subtilisin/kexin type 2
|
| Other Description |
KEX2-like endoprotease 2|neuroendocrine convertase 2|prohormone convertase 2
|
| Swissprots |
Q8IWA8 Q14927 Q9UJC6 Q5JYQ1 B4DFQ3 P16519 B1ANH9 Q9NQG3 Q9NUG1
|
| Accessions |
AAA59919 AAB32656 AAC51862 AAD14202 EAX10279 EAX10280 EAX10281 P16519 AK091505 AK294200 BAG57514 AK312341 BAG35262 BC001905 BC005815 AAH05815 BC040546 AAH40546 BM893758 BP384064 CD519990 DA147868 DA148468 DB173053 DQ892675 ABM83601 DQ895917 ABM86843 HY137524 J05252 AAA60032 NM_001201528 NP_001188457 NM_001201529 NP_001188458 NM_002594 NP_002585
|
| Function |
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells. {ECO:0000269|PubMed:9287128}.
|
| Subcellular Location |
Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules.
|
![Western Blot: Proprotein Convertase 2 Overexpression Lysate (Adult Normal) [NBL1-14190] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Proprotein Convertase 2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2307_Proprotein%2520Convertase%25202%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14190-img0002.jpg)