Gene Symbol | PCSK2 |
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Entrez Gene | 5126 |
Alt Symbol | NEC 2, NEC-2, NEC2, PC2, SPC2 |
Species | Human |
Gene Type | protein-coding |
Description | proprotein convertase subtilisin/kexin type 2 |
Other Description | KEX2-like endoprotease 2|neuroendocrine convertase 2|prohormone convertase 2 |
Swissprots | Q8IWA8 Q14927 Q9UJC6 Q5JYQ1 B4DFQ3 P16519 B1ANH9 Q9NQG3 Q9NUG1 |
Accessions | AAA59919 AAB32656 AAC51862 AAD14202 EAX10279 EAX10280 EAX10281 P16519 AK091505 AK294200 BAG57514 AK312341 BAG35262 BC001905 BC005815 AAH05815 BC040546 AAH40546 BM893758 BP384064 CD519990 DA147868 DA148468 DB173053 DQ892675 ABM83601 DQ895917 ABM86843 HY137524 J05252 AAA60032 NM_001201528 NP_001188457 NM_001201529 NP_001188458 NM_002594 NP_002585 |
Function | Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells. {ECO:0000269|PubMed:9287128}. |
Subcellular Location | Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules. |
PC2 CRISPR/Cas9 KO Plasmid (h) - sc-416836 from Santa Cruz Biotechnology
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PC2 HDR Plasmid (h) - sc-416836-HDR from Santa Cruz Biotechnology
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PC2 Double Nickase Plasmid (h) - sc-416836-NIC from Santa Cruz Biotechnology
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PC2 Double Nickase Plasmid (h2) - sc-416836-NIC-2 from Santa Cruz Biotechnology
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PC2 CRISPR Activation Plasmid (h) - sc-416836-ACT from Santa Cruz Biotechnology
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PC2 CRISPR Activation Plasmid (h2) - sc-416836-ACT-2 from Santa Cruz Biotechnology
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PC2 Lentiviral Activation Particles (h) - sc-416836-LAC from Santa Cruz Biotechnology
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PC2 Lentiviral Activation Particles (h2) - sc-416836-LAC-2 from Santa Cruz Biotechnology
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PC2 siRNA (h) - sc-40884 from Santa Cruz Biotechnology
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PC2 shRNA Plasmid (h) - sc-40884-SH from Santa Cruz Biotechnology
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PC2 shRNA (h) Lentiviral Particles - sc-40884-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU002351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16500 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16500 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11536 from Sigma-Aldrich
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PCSK2 siRNA (Human) - CRH3408 from Cohesion Biosciences
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shRNA set against Human PCSK2 (NM_002594.3) - SHH372012 from Creative biogene
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Human PCSK2 siRNA - orb263910 from Biorbyt
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PCSK2 shRNA Plasmid (Human) - CHH3408 from Cohesion Biosciences
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PCSK2 miRNA 3'UTR clone - MiUTR4H-TG06534 from Creative biogene
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