PCSK2

Gene Symbol PCSK2
Entrez Gene 5126
Alt Symbol NEC 2, NEC-2, NEC2, PC2, SPC2
Species Human
Gene Type protein-coding
Description proprotein convertase subtilisin/kexin type 2
Other Description KEX2-like endoprotease 2|neuroendocrine convertase 2|prohormone convertase 2
Swissprots Q8IWA8 Q14927 Q9UJC6 Q5JYQ1 B4DFQ3 P16519 B1ANH9 Q9NQG3 Q9NUG1
Accessions AAA59919 AAB32656 AAC51862 AAD14202 EAX10279 EAX10280 EAX10281 P16519 AK091505 AK294200 BAG57514 AK312341 BAG35262 BC001905 BC005815 AAH05815 BC040546 AAH40546 BM893758 BP384064 CD519990 DA147868 DA148468 DB173053 DQ892675 ABM83601 DQ895917 ABM86843 HY137524 J05252 AAA60032 NM_001201528 NP_001188457 NM_001201529 NP_001188458 NM_002594 NP_002585
Function Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells. {ECO:0000269|PubMed:9287128}.
Subcellular Location Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules.

PC2 (D1E1S) XP ® Rabbit mAb - 14013 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1E1S
Western blot analysis of extracts from TT and OVCAR8 cells using PC2 (D1E1S) XP ® Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

PC2 (E-8) - sc-374140 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PC2 (E-8): sc-374140. Western blot analysis of PC2 expression in non-transfected: sc-117752 (A) and human PC2 transfected: sc-172360 (B) 293T whole cell lysates.

PC2 (C-19) - sc-22893 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PC2 (C-19): sc-22893. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of Islets of Langerhans.

PC2 (H-20) - sc-22891 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PC2 (H-20): sc-22891. Western blot analysis of PC2 expression in SK-N-SH (A) and BC<sub>3</sub>H1 (B) whole cell lysates.

PC2 (H-68) - sc-30166 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PC2 (H-68): sc-30166. Western blot analysis of PC2 expression in SK-N-SH whole cell lysate.

Anti-Proprotein Convertase 2 antibody - ab11787 from Abcam

Prices $359.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-Proprotein Convertase 2 antibody - ab85261 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Proprotein Convertase 2 antibody (ab85261) at 1/50 dilution + K-562 cell line lysates at 35 µg

Anti-Proprotein Convertase 2 antibody - ab12275 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Proprotein Convertase 2 antibody - ab28572 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Proprotein Convertase 2 antibody - Aminoterminal end - ab28571 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lanes 1 - 6 : Anti-Proprotein Convertase 2 antibody - Aminoterminal end (ab28571) at 1/1000 dilutionLane 7 : Lane 1 : DU 145 Conditioned Media SFLane 2 : DU 145 Conditioned Media treated with TPALane 3 : DU 145 Conditioned Media treated with IL1-betaLane 4 : Hs1. Tes Conditioned Media SFLane 5 : Hs1. Tes Conditioned Media treated with TPALane 6 : Hs1. Tes Conditioned Media treated with IL1-betaLane 7 : Hs1. Tes Conditioned Media treated with TNF-alphaLysates/proteins at 20 µl per lane.

Anti-Proprotein Convertase 2 antibody - N-terminal - ab135808 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Proprotein Convertase 2 antibody - N-terminal (ab135808) at 1/50 dilution + mouse cerebellum tissue lysates at 35 µg

Anti-PCSK2 Antibody (aa87-116) - LS-C100271 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human brain tissue reacted with PCSK2 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-PCSK2 Antibody - LS-C17372 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PCSK2 Antibody - LS-C42693 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PCSK2 Antibody (aa110-638, clone 11n157) - LS-C184874 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 11n157

Anti-PCSK2 Antibody (aa1-529) IHC-plus™ - LS-B11396 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-PCSK2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11396 dilution 1:200.

Anti-PCSK2 Antibody (clone 3H4) - LS-C197856 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3H4
Detection limit for recombinant GST tagged PCSK2 is 0.3 ng/ml as a capture antibody.

Anti-PCSK2 Antibody (aa351-400) - LS-C135548 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PCSK2 antibody LS-C135548 Western blot of HeLa lysate.

Anti-PCSK2 Antibody (aa318-346) - LS-C100272 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human brain tissue reacted with PCSK2 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-PCSK2 Antibody (aa110-125) - LS-C313203 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
PCSK2 antibody. IHC(P): Rat Pancreas Tissue.

Proprotein Convertase 2/PCSK2 Antibody - AF6018 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal

Proprotein Convertase 2/PCSK2 Antibody (694009) - MAB6018 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 694009
Western blot shows lysates of human brain (cerebellum) tissue. PVDF Membrane was probed with 2 µg/mL of Human Proprotein Convertase 2/PCSK2 Monoclonal Antibody (Catalog # MAB6018) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for Proprotein Convertase 2/PCSK2 at approximately 75 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Proprotein Convertase 2/PCSK2 Antibody - NBP2-30086 from Novus Biologicals

Prices $299.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Proprotein Convertase 2/PCSK2 Antibody [NBP2-30086] - Western blot analysis of PCSK2 Antibody (N-term) (NBP2-30086) in mouse cerebellum tissue lysates (35ug/lane). PCSK2 (arrow) was detected using the purified Pab.

Proprotein Convertase 2/PCSK2 Antibody - NBP1-69146 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Proprotein Convertase 2 Antibody [NBP1-69146] - Titration: 0.2-1 ug/ml, Positive Control: Hela cell lysate.

Proprotein Convertase 2/PCSK2 Antibody - H00005126-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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