Gene Symbol |
CBX2
|
Entrez Gene |
84733
|
Alt Symbol |
CDCA6, M33, SRXY5
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
chromobox homolog 2
|
Other Description |
Pc class homolog|cell division cycle associated 6|chromobox homolog 2 (Pc class homolog, Drosophila)|chromobox protein homolog 2|modifier 3
|
Swissprots |
Q9BTB1 Q14781 Q0VDA5
|
Accessions |
CAA54839 EAW89568 EAW89569 Q14781 AL157459 BC004252 AAH04252 BC119759 AAI19760 BC119760 AAI19761 BC156118 AAI56119 BC157074 AAI57075 BX110913 CN367085 CN367087 CN367098 CV815254 DB452048 EU446542 ABZ92071 XM_011525382 XP_011523684 XM_011525383 XP_011523685 NM_005189 NP_005180 NM_032647 NP_116036
|
Function |
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression. {ECO:0000269|PubMed:19361780, ECO:0000269|PubMed:21282530}.
|
Subcellular Location |
Nucleus {ECO:0000269|PubMed:21282530}.
|