Gene Symbol | CBX2 |
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Entrez Gene | 84733 |
Alt Symbol | CDCA6, M33, SRXY5 |
Species | Human |
Gene Type | protein-coding |
Description | chromobox homolog 2 |
Other Description | Pc class homolog|cell division cycle associated 6|chromobox homolog 2 (Pc class homolog, Drosophila)|chromobox protein homolog 2|modifier 3 |
Swissprots | Q9BTB1 Q14781 Q0VDA5 |
Accessions | CAA54839 EAW89568 EAW89569 Q14781 AL157459 BC004252 AAH04252 BC119759 AAI19760 BC119760 AAI19761 BC156118 AAI56119 BC157074 AAI57075 BX110913 CN367085 CN367087 CN367098 CV815254 DB452048 EU446542 ABZ92071 XM_011525382 XP_011523684 XM_011525383 XP_011523685 NM_005189 NP_005180 NM_032647 NP_116036 |
Function | Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression. {ECO:0000269|PubMed:19361780, ECO:0000269|PubMed:21282530}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:21282530}. |
M33 CRISPR/Cas9 KO Plasmid (h) - sc-402604 from Santa Cruz Biotechnology
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M33 HDR Plasmid (h) - sc-402604-HDR from Santa Cruz Biotechnology
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M33 Double Nickase Plasmid (h) - sc-402604-NIC from Santa Cruz Biotechnology
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M33 Double Nickase Plasmid (h2) - sc-402604-NIC-2 from Santa Cruz Biotechnology
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M33 CRISPR Activation Plasmid (h) - sc-402604-ACT from Santa Cruz Biotechnology
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M33 CRISPR Activation Plasmid (h2) - sc-402604-ACT-2 from Santa Cruz Biotechnology
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M33 Lentiviral Activation Particles (h) - sc-402604-LAC from Santa Cruz Biotechnology
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M33 Lentiviral Activation Particles (h2) - sc-402604-LAC-2 from Santa Cruz Biotechnology
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M33 siRNA (h) - sc-38189 from Santa Cruz Biotechnology
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M33 shRNA Plasmid (h) - sc-38189-SH from Santa Cruz Biotechnology
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M33 shRNA (h) Lentiviral Particles - sc-38189-V from Santa Cruz Biotechnology
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Cbx2 RNAi - H00084733-R02 from Novus Biologicals
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Cbx2 RNAi - H00084733-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN5426 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5426 from Sigma-Aldrich
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CBX2 siRNA (Human) - CRJ3605 from Cohesion Biosciences
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CBX2 - MBS8221835 from MyBioSource
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shRNA set against Human CBX2 (NM_032647.3) - SHH255497 from Creative biogene
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Human CBX2 siRNA - orb274106 from Biorbyt
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CBX2 shRNA Plasmid (Human) - CHJ3605 from Cohesion Biosciences
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CBX2 miRNA 3'UTR clone - MiUTR4H-TG01663 from Creative biogene
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