IL15RA

Gene Symbol IL15RA
Entrez Gene 3601
Alt Symbol CD215
Species Human
Gene Type protein-coding
Description interleukin 15 receptor, alpha
Other Description interleukin 15 receptor alpha isoform EM2|interleukin 15 receptor alpha isoform IC2|interleukin 15 receptor alpha isoform IC3|interleukin 15 receptor alpha isoform IC4|interleukin 15 receptor alpha isoform IC5|interleukin 15 receptor alpha isoform IC6|interleukin 15 receptor alpha isoform IC7|interleukin 15 receptor alpha isoform IC8|interleukin-15 receptor subunit alpha
Swissprots Q6B0J2 Q13261 Q7LDR4 Q3B769 Q5JVA2 Q5JVA4 B4E2C2 Q7Z609 Q5JVA1
Accessions AAP69528 CCA64145 CCA64146 EAW86415 EAW86416 EAW86417 EAW86418 EAW86419 EAW86420 EAW86421 EAW86422 Q13261 AA847313 AF035279 AAB88175 AK304211 BAG65084 BC065506 AAH65506 BC074726 AAH74726 BC107777 AAI07778 BC121140 AAI21141 BC121141 AAI21142 BM546106 CR457064 CAG33345 CR542023 CAG46820 DC298692 HQ401283 AEP26933 JX987304 AFY11387 JX987305 AFY11388 JX987306 AFY11389 JX987307 AFY11390 JX987308 AFY11391 JX987309 AFY11392 JX987310 AFY11393 JX987311 AFY11394 U31628 AAC50312 XM_011519461 XP_011517763 XM_011519462 XP_011517764 XM_011519463 XP_011517765 XM_011519464 XP_011517766 XM_011519465 XP_011517767 XM_011519466 XP_011517768 XM_011519467 XP_011517769 XM_011519468 XP_011517770 XM_011519469 XP_011517771 XM_011519470 XP_011517772 XM_011519471 XP_011517773 XM_011519472 XP_011517774 XM_011519473 XP_011517775 XM_011519474 XP_011517776 XM_011519475 XP_011517777 XM_011519476 XP_011517778 XM_011519477 XP_011517779 NM_001243539 NP_001230468 NM_001256765 NP_001243694 NM_002189 NP_002180 NM_172200 NP_751950 NR_046362
Function High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK. {ECO:0000269|PubMed:11714793, ECO:0000269|PubMed:8530383}.
Subcellular Location Isoform 8: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Tissue Specificity Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures. {ECO:0000269|PubMed:10480910, ECO:0000269|PubMed:12114302, ECO:0000269|PubMed:8530383}.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Intestinal immune network for IgA production, HTLV-I infection

IL-15Rα (G-3) - sc-374023 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-15Rα (G-3): sc-374023. Western blot analysis of IL-15Rα expression in Raji whole cell lysate.

IL-15Rα (G-7) - sc-271366 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-15Rα (G-7): sc-271366. Western blot analysis of IL-15Rα expression in Raji whole cell lysate.

IL-15Rα (H-107) - sc-9172 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-15Rα (H-107): sc-9172. Western blot analysis of soluble IL-15Rα expression in Raji (A) and K-562 (B) whole cell lysates.

IL-15Rα (N-19) - sc-1524 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IL-15Rα (N-19): sc-1524. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse heart tissue showing membrane localization.

IL-15Rα (N-20) - sc-5526 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IL-15Rα (N-20): sc-5526. Western blot analysis of IL-15Rα expression in Raji (A), MOLT-4 (B), HuT 78 (C), U-698-M (D) and Caco-2 (E) whole cell lysates.

Anti-IL15RA antibody - ab183113 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL15RA antibody (ab183113) at 1/200 dilutionLane 1 : Human liver cancer tissue lysateLane 2 : Human colon cancer tissue lysateLane 3 : Human fetal kidney tissue lysateLysates/proteins at 30 µg per lane.SecondaryGoat Anti-rabbit HRP at 1/10000 dilution

Anti-IL15RA antibody - ab137005 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-IL15RA antibody (ab137005) at 1/500 dilution + HeLa cell lysate at 30 µg

Anti-IL15RA antibody - ab138756 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-IL15RA antibody (ab138756) at 1/100 dilution + K562 cell lysate at 35 µg

Anti-IL15RA antibody - ab128316 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-IL15RA antibody (ab128316) at 1 µg/ml + Mouse liver lysate at 10 µg

Anti-IL15RA antibody - ab55285 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab55285 IL15RA antibody at 1ug/ml.

Anti-IL15RA antibody [EP6663] - ab140618 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP6663
All lanes : Anti-IL15RA antibody [EP6663] (ab140618) at 1/1000 dilutionLane 1 : Human fetal kidney lysateLane 2 : Raji cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit IgG at 1/2000 dilution

Anti-IL15RA antibody [JM7A4] - ab91270 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone JM7A4
ab91270 staining IL15RA in normal Human PBMCs by Flow cytometry. Normal Human PBMCs were isolated, and cultured in standard conditions for 3 hours. Non adherent cells were removed from culture, and remaining cells were stimulated with LPS and IFN-? for 24 hours. Open/green histogram; stained with 0.25 µg of Purified Mouse IgG2b Isotype Control Closed/blue histogram; stained with 0.25 µg of ab91270. Detection utilised Biotin Anti-Mouse IgG and SAv-PE. Cells in the large scatter population were used for analysis.

Anti-IL15RA antibody [MM0369-5M53] - ab89894 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0369-5M53

Anti-IL15RA Antibody (Extracellular Domain) - LS-C70951 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-IL15RA Antibody (Pro129) - LS-C192148 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL15RA Antibody (aa79-106, AP) - LS-C260089 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL15RA Antibody (aa79-106, Biotin) - LS-C260091 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL15RA Antibody (aa79-106, APC) - LS-C260090 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL15RA Antibody (aa79-106, FITC) - LS-C260092 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL15RA Antibody (aa79-106, Azide-free, HRP) - LS-C260093 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL15RA Antibody (aa51-100) - LS-C151526 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IL15RA antibody Western Blot of Mouse Liver.

Anti-IL15RA Antibody (aa80-129) - LS-C292093 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL15RA Antibody (aa79-106, PE) - LS-C260094 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL15RA Antibody (aa78-106) - LS-C322203 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL15RA Antibody (Extracellular Domain, CF) - LS-C70952 from LifeSpan Bioscience

Prices $495.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
EL-4 cells were stained with LS-C70952 or isotype control.
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