IL15RA
| Gene Symbol | IL15RA |
|---|---|
| Entrez Gene | 3601 |
| Alt Symbol | CD215 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 15 receptor, alpha |
| Other Description | interleukin 15 receptor alpha isoform EM2|interleukin 15 receptor alpha isoform IC2|interleukin 15 receptor alpha isoform IC3|interleukin 15 receptor alpha isoform IC4|interleukin 15 receptor alpha isoform IC5|interleukin 15 receptor alpha isoform IC6|interleukin 15 receptor alpha isoform IC7|interleukin 15 receptor alpha isoform IC8|interleukin-15 receptor subunit alpha |
| Swissprots | Q6B0J2 Q13261 Q7LDR4 Q3B769 Q5JVA2 Q5JVA4 B4E2C2 Q7Z609 Q5JVA1 |
| Accessions | AAP69528 CCA64145 CCA64146 EAW86415 EAW86416 EAW86417 EAW86418 EAW86419 EAW86420 EAW86421 EAW86422 Q13261 AA847313 AF035279 AAB88175 AK304211 BAG65084 BC065506 AAH65506 BC074726 AAH74726 BC107777 AAI07778 BC121140 AAI21141 BC121141 AAI21142 BM546106 CR457064 CAG33345 CR542023 CAG46820 DC298692 HQ401283 AEP26933 JX987304 AFY11387 JX987305 AFY11388 JX987306 AFY11389 JX987307 AFY11390 JX987308 AFY11391 JX987309 AFY11392 JX987310 AFY11393 JX987311 AFY11394 U31628 AAC50312 XM_011519461 XP_011517763 XM_011519462 XP_011517764 XM_011519463 XP_011517765 XM_011519464 XP_011517766 XM_011519465 XP_011517767 XM_011519466 XP_011517768 XM_011519467 XP_011517769 XM_011519468 XP_011517770 XM_011519469 XP_011517771 XM_011519470 XP_011517772 XM_011519471 XP_011517773 XM_011519472 XP_011517774 XM_011519473 XP_011517775 XM_011519474 XP_011517776 XM_011519475 XP_011517777 XM_011519476 XP_011517778 XM_011519477 XP_011517779 NM_001243539 NP_001230468 NM_001256765 NP_001243694 NM_002189 NP_002180 NM_172200 NP_751950 NR_046362 |
| Function | High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK. {ECO:0000269|PubMed:11714793, ECO:0000269|PubMed:8530383}. |
| Subcellular Location | Isoform 8: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane. |
| Tissue Specificity | Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures. {ECO:0000269|PubMed:10480910, ECO:0000269|PubMed:12114302, ECO:0000269|PubMed:8530383}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Intestinal immune network for IgA production, HTLV-I infection |
IL-15Rα CRISPR/Cas9 KO Plasmid (h) - sc-416909 from Santa Cruz Biotechnology
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IL-15Rα HDR Plasmid (h) - sc-416909-HDR from Santa Cruz Biotechnology
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IL-15Rα Double Nickase Plasmid (h) - sc-416909-NIC from Santa Cruz Biotechnology
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IL-15Rα Double Nickase Plasmid (h2) - sc-416909-NIC-2 from Santa Cruz Biotechnology
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IL-15Rα CRISPR Activation Plasmid (h) - sc-416909-ACT from Santa Cruz Biotechnology
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IL-15Rα CRISPR Activation Plasmid (h2) - sc-416909-ACT-2 from Santa Cruz Biotechnology
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IL-15Rα Lentiviral Activation Particles (h) - sc-416909-LAC from Santa Cruz Biotechnology
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IL-15Rα Lentiviral Activation Particles (h2) - sc-416909-LAC-2 from Santa Cruz Biotechnology
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IL-15Rα siRNA (h) - sc-40051 from Santa Cruz Biotechnology
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IL-15Rα shRNA Plasmid (h) - sc-40051-SH from Santa Cruz Biotechnology
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IL-15Rα shRNA (h) Lentiviral Particles - sc-40051-V from Santa Cruz Biotechnology
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IL-15 R alpha RNAi - H00003601-R04 from Novus Biologicals
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MISSION® esiRNA - EHU089841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10573 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10573 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05877 from Sigma-Aldrich
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IL15RA siRNA (Human) - CRH2409 from Cohesion Biosciences
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IL-15 R alpha RNAi - H00003601-R03 from Novus Biologicals
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IL15RA - MBS8200752 from MyBioSource
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shRNA set against Human IL15RA (NM_002189.3) - SHH318273 from Creative biogene
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Human IL15RA siRNA - orb262911 from Biorbyt
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IL15RA shRNA Plasmid (Human) - CHH2409 from Cohesion Biosciences
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IL15RA miRNA 3'UTR clone - MiUTR3H-03861 from Creative biogene
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IL15RA miRNA 3'UTR clone - MiUTR3H-03862 from Creative biogene
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