Gene Symbol | SF3B1 |
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Entrez Gene | 23451 |
Alt Symbol | Hsh155, MDS, PRP10, PRPF10, SAP155, SF3b155 |
Species | Human |
Gene Type | protein-coding |
Description | splicing factor 3b, subunit 1, 155kDa |
Other Description | SAP 155|pre-mRNA processing 10|pre-mRNA splicing factor SF3b, 155 kDa subunit|spliceosome-associated protein 155|splicing factor 3B subunit 1|splicing factor 3b, subunit 1, 155kD |
Swissprots | E9PCH3 O75533 |
Accessions | EAW70146 O75533 AF054284 AAC97189 AF070540 AAC28633 AF086296 AK057684 AK290470 BAF83159 AK294851 BAG57955 AK308122 AL137410 CAB70728 BC015530 AAH15530 BC029418 AAH29418 BC039020 BC046140 BC056155 AAH56155 BC064335 BC107883 AAI07884 BE168209 BE168220 CD692669 HY054349 XM_011510867 XP_011509169 XM_011510868 XP_011509170 XR_241300 XR_241302 NM_001005526 NP_001005526 NM_001308824 NP_001295753 NM_012433 NP_036565 |
Function | Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. |
Subcellular Location | Nucleus speckle. Note=During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm. |
Top Pathways | Spliceosome |
Human SAP155 peptide - ab39577 from Abcam
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SF3B1 Antibody Blocking Peptide - LS-E2677 from LifeSpan Bioscience
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SF3B1 Antibody Blocking Peptide - LS-E14921 from LifeSpan Bioscience
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SF3B1-Antibody-N-term-Blocking-peptide - BP13754a from Abgent, a WuXi AppTec company
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SF3B1 Blocking Peptide - 33R-8313 from Fitzgerald
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SF3B1 Blocking Peptide - 33R-5678 from Fitzgerald
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SF3B1 Blocking Peptide - 33R-2699 from Fitzgerald
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SF3B1 Blocking Peptide - 33R-5171 from Fitzgerald
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SAP155 Blocking Peptide - abx063769 from Abbexa
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SAP155 Blocking Peptide - CBP2575 from Cohesion Biosciences
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SF3B1 Peptide - BS5919P from Bioworld Technology
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Recombinant Human Splicing factor 3B subunit 1(SF3B1) ,partial - CSB-YP021125HU CSB-EP021125HU CSB-BP021125HU CSB-MP021125HU from Cusabio
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SF3B1 / SAP155 (transcript variant 2) - TP319649 from Acris Antibodies
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SAP155 Recombinant Protein Antigen - NBP2-47291PEP from Novus Biologicals
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SF3B1 Peptide, Human - M34GP14098H from Creative Peptides
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SF3B1 fusion protein - Ag26689 from Proteintech Group
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Recombinant Splicing Factor 3B Subunit 1 (SF3B1) - RPU50285 from Biomatik
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Splicing Factor 3B Subunit 1 (SF3B1), Recombinant Protein - MBS2086883 from MyBioSource
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Splicing factor 3B subunit 1 (SF3B1), partial, Recombinant Protein - MBS1019448 from MyBioSource
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SF3B1 peptide - orb218438 from Biorbyt
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