SF3B1
| Gene Symbol | SF3B1 |
|---|---|
| Entrez Gene | 23451 |
| Alt Symbol | Hsh155, MDS, PRP10, PRPF10, SAP155, SF3b155 |
| Species | Human |
| Gene Type | protein-coding |
| Description | splicing factor 3b, subunit 1, 155kDa |
| Other Description | SAP 155|pre-mRNA processing 10|pre-mRNA splicing factor SF3b, 155 kDa subunit|spliceosome-associated protein 155|splicing factor 3B subunit 1|splicing factor 3b, subunit 1, 155kD |
| Swissprots | E9PCH3 O75533 |
| Accessions | EAW70146 O75533 AF054284 AAC97189 AF070540 AAC28633 AF086296 AK057684 AK290470 BAF83159 AK294851 BAG57955 AK308122 AL137410 CAB70728 BC015530 AAH15530 BC029418 AAH29418 BC039020 BC046140 BC056155 AAH56155 BC064335 BC107883 AAI07884 BE168209 BE168220 CD692669 HY054349 XM_011510867 XP_011509169 XM_011510868 XP_011509170 XR_241300 XR_241302 NM_001005526 NP_001005526 NM_001308824 NP_001295753 NM_012433 NP_036565 |
| Function | Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. |
| Subcellular Location | Nucleus speckle. Note=During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm. |
| Top Pathways | Spliceosome |
SAP 155 CRISPR/Cas9 KO Plasmid (h) - sc-402925 from Santa Cruz Biotechnology
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SAP 155 HDR Plasmid (h) - sc-402925-HDR from Santa Cruz Biotechnology
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SAP 155 Double Nickase Plasmid (h) - sc-402925-NIC from Santa Cruz Biotechnology
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SAP 155 Double Nickase Plasmid (h2) - sc-402925-NIC-2 from Santa Cruz Biotechnology
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SAP 155 CRISPR Activation Plasmid (h) - sc-402925-ACT from Santa Cruz Biotechnology
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SAP 155 CRISPR Activation Plasmid (h2) - sc-402925-ACT-2 from Santa Cruz Biotechnology
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SAP 155 Lentiviral Activation Particles (h) - sc-402925-LAC from Santa Cruz Biotechnology
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SAP 155 Lentiviral Activation Particles (h2) - sc-402925-LAC-2 from Santa Cruz Biotechnology
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SAP 155 siRNA (h) - sc-94471 from Santa Cruz Biotechnology
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SAP 155 shRNA Plasmid (h) - sc-94471-SH from Santa Cruz Biotechnology
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SAP 155 shRNA (h) Lentiviral Particles - sc-94471-V from Santa Cruz Biotechnology
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SAP155 RNAi - H00023451-R02 from Novus Biologicals
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SAP155 RNAi - H00023451-R01 from Novus Biologicals
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MISSION® esiRNA - EHU131531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19185 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19185 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03154 from Sigma-Aldrich
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SF3B1 siRNA (Human) - CRH8278 from Cohesion Biosciences
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SF3B1 - MBS8228799 from MyBioSource
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shRNA set against Human SF3B1 (NM_012433.2) - SHH405808 from Creative biogene
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shRNA set against Human SF3B1(NM_001005526.1) - SHR219210 from Creative biogene
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shRNA set against Human SF3B1(NM_012433.2) - SHR219246 from Creative biogene
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Human SF3B1 siRNA - orb268780 from Biorbyt
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SF3B1 shRNA Plasmid (Human) - CHH8278 from Cohesion Biosciences
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SF3B1 miRNA 3'UTR clone - MiUTR1H-09323 from Creative biogene
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