| Gene Symbol |
SPRED1
|
| Entrez Gene |
161742
|
| Alt Symbol |
NFLS, PPP1R147, hSpred1, spred-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sprouty-related, EVH1 domain containing 1
|
| Other Description |
protein phosphatase 1, regulatory subunit 147|sprouty-related, EVH1 domain-containing protein 1|suppressor of Ras/MAPK activation
|
| Swissprots |
Q8N256 Q05D53 B2RPJ8 Q7Z699
|
| Accessions |
CCQ43858 EAW92368 Q7Z699 AK091222 BAC03614 AK095219 AY299089 AAP59414 BC018015 AAH18015 BC137480 AAI37481 BC137481 AAI37482 BX538234 DA405650 XM_005254202 XP_005254259 XM_005254203 XP_005254260 XM_011521288 XP_011519590 XM_011521289 XP_011519591 XM_011521290 XP_011519592 NM_152594 NP_689807
|
| Function |
Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:16115197}; Peripheral membrane protein {ECO:0000269|PubMed:16115197}. Membrane, caveola {ECO:0000269|PubMed:16115197}; Peripheral membrane protein {ECO:0000269|PubMed:16115197}. Nucleus {ECO:0000269|PubMed:16115197}. Note=Localized in cholesterol-rich membrane raft/caveola fractions.
|
| Tissue Specificity |
Weakly expressed in embryonic cell line HEK293. {ECO:0000269|PubMed:15580519}.
|
| Top Pathways |
Jak-STAT signaling pathway
|