EZR

Gene Symbol EZR
Entrez Gene 7430
Alt Symbol CVIL, CVL, HEL-S-105, VIL2
Species Human
Gene Type protein-coding
Description ezrin
Other Description cytovillin 2|epididymis secretory protein Li 105|p81|villin 2 (ezrin)|villin-2
Swissprots Q96CU8 E1P5A8 P15311 Q4VX75 P23714 Q9NSJ4
Accessions EAW47646 EAW47647 P15311 AF187552 AAD56713 AF188896 AAF03154 AF188897 AAF03155 AF189213 AAF03156 AF190059 AAF03158 AF199015 AAF09502 AI366687 AK129727 AK296738 BAH12423 AK299456 BAH13038 AK312597 BAG35489 AK316031 BAH14402 AL162086 CAB82418 BC013903 AAH13903 BC068458 AAH68458 DA754543 DA783190 DQ892754 ABM83680 DQ895999 ABM86977 FJ224318 ACI46010 J05021 AAA61278 X51521 CAA35893 XM_011536110 XP_011534412 NM_001111077 NP_001104547 NM_003379 NP_003370
Function Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}.
Subcellular Location Apical cell membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection {ECO:0000269|PubMed:18046454}. Cell projection, microvillus membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection, ruffle membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18046454}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18046454}. Note=Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side). {ECO:0000250}.
Tissue Specificity Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied. {ECO:0000269|PubMed:15797715}.
Top Pathways Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Gastric acid secretion, MicroRNAs in cancer, Proteoglycans in cancer

Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb (Biotinylated) - 13756 from Cell Signaling Technology

Host Rabbit
Clonality Monoclonal
Clone 41A3
Western blot analysis of extracts from COS, C6, and C2C12 cells using Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb (Biotinylated).

Phospho-Ezrin (Tyr353) Antibody - 3144 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from A431 cells, untreated or EGF-treated, using Phospho-Ezrin (Tyr353) Antibody (upper) or Ezrin/Radixin/Moesin Antibody #3142 (lower).

Phospho-Ezrin (Tyr353) (D66D3) Rabbit mAb - 5484 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D66D3
Western blot analysis of extracts from A-431 cells, untreated or treated with hEGF #8916 (100 ng/ml, 5 minutes), using Phospho-Ezrin (Tyr353) (D66D3) Rabbit mAb (upper) or Ezrin/Radixin/Moesin Antibody #3142 (lower).

Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (48G2) Rabbit mAb - 3726 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 48G2
Western blot analysis of various cell extracts, using Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (48G2) Rabbit mAb.

Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb - 3149 from Cell Signaling Technology

Host Rabbit
Clonality Monoclonal
Clone 41A3
Western blot analysis of various cell extracts, using Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb.

Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) Antibody - 3141 from Cell Signaling Technology

Prices $287.00, $678.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from A431 cells, untreated or EGF-treated, using Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) Antibody (left) or Ezrin/Radixin/Moesin Antibody #3142 (right).

Ezrin/Radixin/Moesin Antibody - 3142 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using Ezrin/Radixin/Moesin Antibody.

Ezrin Antibody - 3145 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa, NIH/3T3, C6 and COS cells, using Ezrin Antibody.

Ezrin (3C12) - sc-58758 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ezrin (3C12): sc-58758. Western blot analysis of Ezrin expression in A-431 (A), HeLa (B) and Jurkat (C) whole cell lysates.

Ezrin (A-4) - sc-271456 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ezrin (A-4): sc-271456. Western blot analysis of Ezrin expression in non-transfected 293T: sc-117752 (A), human Ezrin transfected 293T: sc-170691 (B) and Ramos (C) whole cell lysates.

Ezrin (4A5) - sc-32759 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ezrin (4A5): sc-32759. Western blot analysis of Ezrin expression in Jurkat (A), A-431 (B), HeLa (C) and F9 (D) whole cell lysates.

Ezrin (C-15) - sc-6409 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ezrin (C-15): sc-6409. Western blot analysis of ERM family members in A-431 (A), HeLa (B), Jurkat (C), NIH/3T3 (D) and F9 (E) whole cell lysates and rat liver extract (F).

Ezrin (C-4) - sc-271541 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ezrin (C-4): sc-271541. Immunoperoxidase staining of formalin fixed, paraffin-embedded human urinary bladder tissue showing cytoplasmic staining of urothelial cells.

Ezrin (C-19) - sc-6407 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ezrin (C-19): sc-6407. Western blot analysis of ERM family members in A-431 (A), HeLa (B), Jurkat (C), NIH/3T3 (D) and F9 (E) whole cell lysates and rat liver extract (F).

Ezrin (H-276) - sc-20773 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Ezrin (H-276): sc-20773. Western blot analysis of Ezrin expression in Jurkat (A), A-431 (B), HeLa (C), NIH/3T3 (D) and F9 (E) whole cell lysates.

Ezrin (H-300) - sc-32918 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Ezrin (H-300): sc-32918. Western blot analysis of Ezrin expression in non-transfected: sc-117752 (A) and human Ezrin transfected: sc-170691 (B) 293T whole cell lysates.

Ezrin (4i251) - sc-71080 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ezrin (4i251): sc-71080. Western blot analysis of Ezrin expression in A-431 (A) and HeLa (B) whole cell lysates.

Ezrin (SPM244) - sc-56388 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ezrin (SPM244): sc-56388. Western blot analysis of Ezrin expression in NIH/3T3 (A) and F9 (B) whole cell lysates.

Ezrin (5G110) - sc-71081 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ezrin (5G110): sc-71081. Western blot analysis of Ezrin expression in non-transfected 293T: sc-117752 (A), human Ezrin transfected 293T: sc-170691 (B) and Ramos (C) whole cell lysates.

Ezrin (6A84) - sc-71082 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ezrin (6A84): sc-71082. Western blot analysis of Ezrin expression in F9 whole cell lysate.

p-Ezrin (G-7) - sc-166858 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of Ezrin phosphorylation in untreated (A,C), and lambda protein phosphatase treated (B,D) Ramos whole cell lysates. Antibodies tested include p-Ezrin (G-7): sc-166858 (A,B) and Ezrin (3C12): sc-58758 (B,D).

p-Ezrin (Tyr 354) - sc-12942 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-Ezrin (Tyr 354): sc-12942. Immunoperoxidase staining of formalin fixed, paraffin-embedded human hippo-campus tissue showing cytoplasmic staining of neuronal cells and glial cells.

p-Ezrin (Tyr 354) - sc-101678 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-Ezrin (Tyr 354): sc-101678. Western blot analysis of phosphorylated Ezrin expression in untreated (A) and EGF-treated (B) A-431 whole cell lysates.

p-Ezrin (Thr 566) - sc-101677 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-Ezrin (Thr 566): sc-101677. Western blot analysis of phosphorylated Ezrin expression in untreated (A) and EGF-treated (B) A-431 whole cell lysates.

Anti-Ezrin (phospho T566) antibody - ab195763 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Ezrin (phospho T566) antibody (ab195763) at 1/500 dilutionLane 1 : EGF treated A431 whole cell lysates with the antigen-specific peptideLane 2 : EGF treated A431 whole cell lysatesLysates/proteins at 12.5 µg per lane.
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