EZR

Gene Symbol	EZR
Entrez Gene	7430
Alt Symbol	CVIL, CVL, HEL-S-105, VIL2
Species	Human
Gene Type	protein-coding
Description	ezrin
Other Description	cytovillin 2|epididymis secretory protein Li 105|p81|villin 2 (ezrin)|villin-2
Swissprots	Q96CU8 E1P5A8 P15311 Q4VX75 P23714 Q9NSJ4
Accessions	EAW47646 EAW47647 P15311 AF187552 AAD56713 AF188896 AAF03154 AF188897 AAF03155 AF189213 AAF03156 AF190059 AAF03158 AF199015 AAF09502 AI366687 AK129727 AK296738 BAH12423 AK299456 BAH13038 AK312597 BAG35489 AK316031 BAH14402 AL162086 CAB82418 BC013903 AAH13903 BC068458 AAH68458 DA754543 DA783190 DQ892754 ABM83680 DQ895999 ABM86977 FJ224318 ACI46010 J05021 AAA61278 X51521 CAA35893 XM_011536110 XP_011534412 NM_001111077 NP_001104547 NM_003379 NP_003370
Function	Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}.
Subcellular Location	Apical cell membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection {ECO:0000269|PubMed:18046454}. Cell projection, microvillus membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection, ruffle membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18046454}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18046454}. Note=Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side). {ECO:0000250}.
Tissue Specificity	Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied. {ECO:0000269|PubMed:15797715}.
Top Pathways	Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Gastric acid secretion, MicroRNAs in cancer, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Ezrin full length protein - ab132942 from Abcam Category Protein Source Wheat germ Species Human

Human Ezrin full length protein - ab132943 from Abcam Category Protein Source Wheat germ Species Human

Human Ezrin peptide - ab42317 from Abcam Category Peptide

Human Ezrin peptide - ab50461 from Abcam Category Peptide Species Human

EZR / Ezrin Antibody Blocking Peptide - LS-E26125 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EZR / Ezrin Antibody Blocking Peptide - LS-E23271 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Ezrin Protein - H00007430-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Ezrin Recombinant Protein - H00007430-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Ezrin blocking peptide - GTX89327-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog

Human EZR protein - orb245830 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human Ezrin protein (His Tag) - orb138835 from Biorbyt Category Protein Prices $476.00, $748.00 Sizes 20 μg, 50 μg Source E. coli Species Human

Human EZR protein - orb244193 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

EZR peptide - orb218088 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

VIL2 Immunizing peptide - orb17990 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

EZR peptide - orb218086 from Biorbyt Category Peptide Prices $357.00, $723.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Zebrafish, Cat

Ezrin (phospho-Thr567) Blocking Peptide - abx063417 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Pig, Zebrafish

Ezrin Blocking Peptide - abx063418 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Pig, Rabbit

Ezrin Blocking Peptide - abx063419 from Abbexa Category Peptide Species Human, Mouse, Rat

Ezrin Blocking Peptide - abx063420 from Abbexa Category Peptide Species Human, Bovine, Chicken, Pig, Zebrafish

Human Cytovillin Protein - abx066271 from Abbexa Category Protein Source E.coli Species Human

Ezrin Peptide - AC21-0955-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Ezrin - H00007430-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Ezrin - H00007430-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Ezrin - H00007430-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Ezrin - H00007430-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

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