| Gene Symbol | EZR |
|---|---|
| Entrez Gene | 7430 |
| Alt Symbol | CVIL, CVL, HEL-S-105, VIL2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ezrin |
| Other Description | cytovillin 2|epididymis secretory protein Li 105|p81|villin 2 (ezrin)|villin-2 |
| Swissprots | Q96CU8 E1P5A8 P15311 Q4VX75 P23714 Q9NSJ4 |
| Accessions | EAW47646 EAW47647 P15311 AF187552 AAD56713 AF188896 AAF03154 AF188897 AAF03155 AF189213 AAF03156 AF190059 AAF03158 AF199015 AAF09502 AI366687 AK129727 AK296738 BAH12423 AK299456 BAH13038 AK312597 BAG35489 AK316031 BAH14402 AL162086 CAB82418 BC013903 AAH13903 BC068458 AAH68458 DA754543 DA783190 DQ892754 ABM83680 DQ895999 ABM86977 FJ224318 ACI46010 J05021 AAA61278 X51521 CAA35893 XM_011536110 XP_011534412 NM_001111077 NP_001104547 NM_003379 NP_003370 |
| Function | Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}. |
| Subcellular Location | Apical cell membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection {ECO:0000269|PubMed:18046454}. Cell projection, microvillus membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection, ruffle membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18046454}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18046454}. Note=Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side). {ECO:0000250}. |
| Tissue Specificity | Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied. {ECO:0000269|PubMed:15797715}. |
| Top Pathways | Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Gastric acid secretion, MicroRNAs in cancer, Proteoglycans in cancer |
Mouse/Human/Rat EZR / Ezrin ELISA Kit (Cell-Based ELISA) - LS-F2985 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-EZR / Ezrin (Tyr353) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1505 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-EZR / Ezrin (Tyr478) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1659 from LifeSpan Bioscience
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Human EZR / Ezrin ELISA Kit (Sandwich ELISA) - LS-F9292 from LifeSpan Bioscience
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Human Cytovillin/Ezrin ELISA Kit - abx052490 from Abbexa
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Human Ezrin ELISA Kit - abx051294 from Abbexa
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Cytovillin/Ezrin, CVL/EZR, Human, ELISA Kit - E-EL-H2079 from ARP American Research Products
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Cytovillin (CVL), Human, ELISA Kit - SEB297Hu from ARP American Research Products
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Cytovillin/ezrin, Human, ELISA Kit - CSB-E09922h from ARP American Research Products
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Cytovillin/ezrin, Human, ELISA Kit - E01C2287 from ARP American Research Products
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Cytovillin/Ezrin, Human, ELISA Kit - YHB0961Hu from ARP American Research Products
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Ezrin, EZR, Human, ELISA Kit - E1297h from ARP American Research Products
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Cytovillin, CVL, Rat, ELISA Kit - E-EL-R0315 from ARP American Research Products
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Cytovillin/Ezrin, CVL/EZR, Rabbit, ELISA Kit - E-EL-RB1216 from ARP American Research Products
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Cytovillin/Ezrin, CVL/EZR, Chicken, ELISA Kit - E-EL-Ch1124 from ARP American Research Products
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Cytovillin/Ezrin, CVL/EZR, Porcine, ELISA Kit - E-EL-P1778 from ARP American Research Products
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Cytovillin/Ezrin, CVL/EZR, Sheep, ELISA Kit - E-EL-S0552 from ARP American Research Products
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Cytovillin/Ezrin, CVL/EZR, Monkey, ELISA Kit - E-EL-MK1583 from ARP American Research Products
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EZR (Human) IP-WB Antibody Pair - H00007430-PW1 from Acris Antibodies
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Human CVL ELISA Kit - HC0487 from NeoScientific
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Anserine CVL ELISA Kit - AC0487 from NeoScientific
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Anserine PROG ELISA Kit - AP0207 from NeoScientific
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Cytovillin, ELISA Kit - MBS092268 from MyBioSource
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Cytovillin, ELISA Kit - MBS746862 from MyBioSource
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Cytovillin, ELISA Kit - MBS025202 from MyBioSource
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