EZR

Gene Symbol	EZR
Entrez Gene	7430
Alt Symbol	CVIL, CVL, HEL-S-105, VIL2
Species	Human
Gene Type	protein-coding
Description	ezrin
Other Description	cytovillin 2|epididymis secretory protein Li 105|p81|villin 2 (ezrin)|villin-2
Swissprots	Q96CU8 E1P5A8 P15311 Q4VX75 P23714 Q9NSJ4
Accessions	EAW47646 EAW47647 P15311 AF187552 AAD56713 AF188896 AAF03154 AF188897 AAF03155 AF189213 AAF03156 AF190059 AAF03158 AF199015 AAF09502 AI366687 AK129727 AK296738 BAH12423 AK299456 BAH13038 AK312597 BAG35489 AK316031 BAH14402 AL162086 CAB82418 BC013903 AAH13903 BC068458 AAH68458 DA754543 DA783190 DQ892754 ABM83680 DQ895999 ABM86977 FJ224318 ACI46010 J05021 AAA61278 X51521 CAA35893 XM_011536110 XP_011534412 NM_001111077 NP_001104547 NM_003379 NP_003370
Function	Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}.
Subcellular Location	Apical cell membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection {ECO:0000269|PubMed:18046454}. Cell projection, microvillus membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection, ruffle membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18046454}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18046454}. Note=Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side). {ECO:0000250}.
Tissue Specificity	Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied. {ECO:0000269|PubMed:15797715}.
Top Pathways	Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Gastric acid secretion, MicroRNAs in cancer, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EZR-Over-expression-Lysate - LY14187a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

VIL2 293T Cell Transient Overexpression Lysate(Denatured) - H00007430-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

EZR overexpression lysate - LY401164 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

EZR overexpression lysate - LY426350 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

EZR 293 Cell Lysate - 401081 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Ezrin Overexpression Lysate (Denatured) - H00007430-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Ezrin Overexpression Lysate (Native) - NBL1-10401 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Ezrin (h2): 293T Lysate - sc-170691 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

EZR Over-expression Lysate Product - GWB-7A9325 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Ezrin Overexpression Lysate (Native) - NBP2-11418 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Ezrin Overexpression Lysate (Denatured) - H00007430-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human EZR Knockdown Stable Cell Line - CSC-DC005163 from Creative biogene Category Cell Line Species Human

Human EZR Knockout Cell Line-HeLa - CSC-RT0546 from Creative biogene Category Cell Line Species Human

EZR Knockout Cell Line-HCT116 - CSC-RT1876 from Creative biogene Category Cell Line Species Human

EZR KO Cell Lysate-HeLa - CLKO-0051 from Creative biogene Category Cell Lysate

EZR KO Cell Lysate-HCT116 - CLKO-1730 from Creative biogene Category Cell Lysate

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