PLTP

Gene Symbol PLTP
Entrez Gene 5360
Alt Symbol BPIFE, HDLCQ9
Species Human
Gene Type protein-coding
Description phospholipid transfer protein
Other Description BPI fold containing family E|lipid transfer protein II
Swissprots B4DDD5 Q9BR07 Q8WTT1 B4DRB4 E1P5N8 A8K006 Q9BSH8 E7EV16 P55058
Accessions AAR87775 EAW75781 EAW75782 EAW75783 EAW75784 EAW75785 EAW75786 EAW75787 P55058 AB076694 BAB79630 AF052157 AK092397 AK092523 AK097009 BAG53407 AK222690 BAD96410 AK289371 BAF82060 AK293150 BAG56696 AK299181 BAG61226 BC005045 AAH05045 BC019847 AAH19847 BC019898 AAH19898 DQ891798 ABM82724 DQ894981 ABM85907 L26232 AAA36443 NM_001242920 NP_001229849 NM_001242921 NP_001229850 NM_006227 NP_006218 NM_182676 NP_872617
Function Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability.
Subcellular Location Secreted.
Tissue Specificity Wide tissue distribution. Placenta > pancreas > lung > kidney > heart > liver > skeletal muscle > brain.
Top Pathways PPAR signaling pathway

PLTP (A-12) - sc-271596 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PLTP (A-12): sc-271596. Western blot analysis of PLTP expression in non-transfected: sc-117752 (A) and human PLTP transfected: sc-170081 (B) 293T whole cell lysates.

PLTP (H-273) - sc-32901 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PLTP (H-273): sc-32901. Western blot analysis of PLTP expression in mouse liver tissue extract.

PLTP (K-16) - sc-30837 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PLTP (N-17) - sc-30835 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PLTP (S-14) - sc-30836 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PLTP antibody - ab18990 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab18990 stained HeLa cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab18990, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-PLTP antibody - ab85562 from Abcam

Prices $407.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ab85562 at a 1/100 dilution staining PLTP in human placenta tissue section by IHC-P.

Anti-PLTP antibody - ab57273 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
PLTP antibody (ab57273) used in immunohistochemistry at 5ug/ml on formalin fixed and paraffin embedded human ovary, clear cell carcinoma tissue.

Anti-PLTP antibody - ab191009 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human placenta tissue, labeling PLTP with ab191009 at 1 μg/ml.

Anti-PLTP antibody - ab85303 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PLTP antibody (ab85303) at 1/50 dilution + HepG2 cell line lysates at 35 µg

Anti-PLTP antibody - ab41635 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PLTP antibody [EPR2925(2)] - ab134066 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2925(2)
All lanes : Anti-PLTP antibody [EPR2925(2)] (ab134066) at 1/1000 dilutionLane 1 : JAR cell lysateLane 2 : HepG2 cell lysateLane 3 : HeLa cell lysateLane 4 : BxPC-3 cell lysateLane 5 : fetal brain lysateLane 6 : fetal lung lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-PLTP antibody - C-terminal - ab189776 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PLTP antibody - C-terminal (ab189776) at 1/500 dilutionLane 1 : 293T cell extractLane 2 : SW620 cell extract

Anti-PLTP Antibody (aa18-493, Biotin) - LS-C131512 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Sheep
Clonality Polyclonal

Anti-PLTP Antibody (aa18-493) - LS-C131511 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-PLTP Antibody (aa292-493) - LS-C311785 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PLTP Antibody (FITC) - LS-C317155 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PLTP Antibody (Biotin) - LS-C317156 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PLTP Antibody (HRP) - LS-C317158 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PLTP Antibody (Internal, clone EPR2925(2)) - LS-C152327 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2925(2)
Western blot analysis on (A) JAR, (B) HepG2, (C) HeLa, (D) BxPC-3, (E) fetal brain, and (F) fetal lung lysates using anti-PLTP antibody.

Anti-PLTP Antibody (aa1-422, Azide-free) - LS-C328277 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PLTP Antibody - LS-C341676 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PLTP Antibody (clone 2F3-G4) - LS-C105012 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F3-G4
Western blot of PLTP expression in transfected 293T cell line by PLTP monoclonal antibody (M01), clone 2F3-G4.

Anti-PLTP Antibody (C-Terminus) IHC-plus™ - LS-B8259 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PLTP antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8259 dilution 5-10 ug/ml.

Anti-PLTP Antibody (aa451-479) - LS-C100277 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human lung carcinoma reacted with PLTP Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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