| Gene Symbol | PLTP |
|---|---|
| Entrez Gene | 5360 |
| Alt Symbol | BPIFE, HDLCQ9 |
| Species | Human |
| Gene Type | protein-coding |
| Description | phospholipid transfer protein |
| Other Description | BPI fold containing family E|lipid transfer protein II |
| Swissprots | B4DDD5 Q9BR07 Q8WTT1 B4DRB4 E1P5N8 A8K006 Q9BSH8 E7EV16 P55058 |
| Accessions | AAR87775 EAW75781 EAW75782 EAW75783 EAW75784 EAW75785 EAW75786 EAW75787 P55058 AB076694 BAB79630 AF052157 AK092397 AK092523 AK097009 BAG53407 AK222690 BAD96410 AK289371 BAF82060 AK293150 BAG56696 AK299181 BAG61226 BC005045 AAH05045 BC019847 AAH19847 BC019898 AAH19898 DQ891798 ABM82724 DQ894981 ABM85907 L26232 AAA36443 NM_001242920 NP_001229849 NM_001242921 NP_001229850 NM_006227 NP_006218 NM_182676 NP_872617 |
| Function | Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Wide tissue distribution. Placenta > pancreas > lung > kidney > heart > liver > skeletal muscle > brain. |
| Top Pathways | PPAR signaling pathway |