NAGPA
| Gene Symbol | NAGPA |
|---|---|
| Entrez Gene | 51172 |
| Alt Symbol | APAA, UCE |
| Species | Human |
| Gene Type | protein-coding |
| Description | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase |
| Other Description | alpha-N-acetylglucosaminyl phosphodiesterase|lysosomal alpha-N-acetylglucosaminidase|mannose 6-phosphate-uncovering enzyme|phosphodiester alpha-GlcNAcase |
| Swissprots | B2RAS1 Q96EJ8 Q9UK23 |
| Accessions | EAW85245 EAW85246 Q9UK23 AF052111 AF187072 AAF08273 AK025570 AK026122 AK092889 AK127952 BAG54605 AK302916 BAG64081 AK314320 BAG36968 BC012194 AAH12194 DA879815 XM_011522517 XP_011520819 XM_011522518 XP_011520820 XM_011522519 XP_011520821 XR_243285 NM_016256 NP_057340 |
| Function | Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P- mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N- acetylglucosaminyltransferases. {ECO:0000269|PubMed:23572527}. |
| Subcellular Location | Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:12058031}; Single-pass type I membrane protein {ECO:0000269|PubMed:12058031}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:12058031}. Note=Cis/medial Golgi. |
| Tissue Specificity | Isoform 2 may be brain-specific. |
| Top Pathways | Lysosome |
NAGPA (N-19) - sc-243576 from Santa Cruz Biotechnology
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NAGPA (Q-18) - sc-243577 from Santa Cruz Biotechnology
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Anti-NAGPA Antibody (aa146-195) - LS-C201526 from LifeSpan Bioscience
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NAGPA Antibody - NBP2-38041 from Novus Biologicals
![Immunohistochemistry: NAGPA Antibody [NBP2-38041] - Staining of human kidney shows strong cytoplasmic positivity in cells in tubules.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_4/23642_NAGPA%2520Antibody-Immunohistochemistry-NBP2-38041-img0001.jpg)
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NAGPA Antibody - H00051172-A01 from Novus Biologicals
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NAGPA Antibody - N-terminal region (ARP47241_P050) - ARP47241_P050 from Aviva Systems Biology
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NAGPA antibody - H00051172-A01 from Acris Antibodies
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Anti-NAGPA (aa 309-408) polyclonal antibody - DPAB-DC2132 from Creative Diagnostics
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Anti-NAGPA (aa 146-195) polyclonal antibody - DPABH-13159 from Creative Diagnostics
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NAGPA-Antibody-N-terminal-region-AI12767 - AI12767 from Abgent, a WuXi AppTec company
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Anti-NAGPA antibody produced in rabbit - HPA064055 from Sigma-Aldrich
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NAGPA antibody - TA342008 from Acris Antibodies
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Anti-NAGPA Antibody (aa146-195, HRP) - LS-C449688 from LifeSpan Bioscience
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Anti-NAGPA Antibody (aa146-195, Biotin) - LS-C449686 from LifeSpan Bioscience
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Anti-NAGPA Antibody (aa146-195, FITC) - LS-C449687 from LifeSpan Bioscience
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Anti-NAGPA Antibody A10711 - A10711 from Boster Bio
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NAGPA Antibody - N-terminal region : Biotin (ARP47241_P050-Biotin) - ARP47241_P050-Biotin from Aviva Systems Biology
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NAGPA Antibody - N-terminal region : FITC (ARP47241_P050-FITC) - ARP47241_P050-FITC from Aviva Systems Biology
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NAGPA Antibody - N-terminal region : HRP (ARP47241_P050-HRP) - ARP47241_P050-HRP from Aviva Systems Biology
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NAGPA antibody (FITC) - orb222265 from Biorbyt
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NAGPA antibody - orb221594 from Biorbyt
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NAGPA Antibody, Biotin conjugated - CSB-PA015417LD01HU from Cusabio
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NAGPA Antibody, FITC conjugated - CSB-PA015417LC01HU from Cusabio
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NAGPA Antibody, HRP conjugated - CSB-PA015417LB01HU from Cusabio
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NAGPA Antibody - CSB-PA015417LA01HU from Cusabio
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