| Gene Symbol |
NAGPA
|
| Entrez Gene |
51172
|
| Alt Symbol |
APAA, UCE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
|
| Other Description |
alpha-N-acetylglucosaminyl phosphodiesterase|lysosomal alpha-N-acetylglucosaminidase|mannose 6-phosphate-uncovering enzyme|phosphodiester alpha-GlcNAcase
|
| Swissprots |
B2RAS1 Q96EJ8 Q9UK23
|
| Accessions |
EAW85245 EAW85246 Q9UK23 AF052111 AF187072 AAF08273 AK025570 AK026122 AK092889 AK127952 BAG54605 AK302916 BAG64081 AK314320 BAG36968 BC012194 AAH12194 DA879815 XM_011522517 XP_011520819 XM_011522518 XP_011520820 XM_011522519 XP_011520821 XR_243285 NM_016256 NP_057340
|
| Function |
Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P- mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N- acetylglucosaminyltransferases. {ECO:0000269|PubMed:23572527}.
|
| Subcellular Location |
Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:12058031}; Single-pass type I membrane protein {ECO:0000269|PubMed:12058031}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:12058031}. Note=Cis/medial Golgi.
|
| Tissue Specificity |
Isoform 2 may be brain-specific.
|
| Top Pathways |
Lysosome
|