NAGPA

Gene Symbol NAGPA
Entrez Gene 51172
Alt Symbol APAA, UCE
Species Human
Gene Type protein-coding
Description N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Other Description alpha-N-acetylglucosaminyl phosphodiesterase|lysosomal alpha-N-acetylglucosaminidase|mannose 6-phosphate-uncovering enzyme|phosphodiester alpha-GlcNAcase
Swissprots B2RAS1 Q96EJ8 Q9UK23
Accessions EAW85245 EAW85246 Q9UK23 AF052111 AF187072 AAF08273 AK025570 AK026122 AK092889 AK127952 BAG54605 AK302916 BAG64081 AK314320 BAG36968 BC012194 AAH12194 DA879815 XM_011522517 XP_011520819 XM_011522518 XP_011520820 XM_011522519 XP_011520821 XR_243285 NM_016256 NP_057340
Function Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P- mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N- acetylglucosaminyltransferases. {ECO:0000269|PubMed:23572527}.
Subcellular Location Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:12058031}; Single-pass type I membrane protein {ECO:0000269|PubMed:12058031}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:12058031}. Note=Cis/medial Golgi.
Tissue Specificity Isoform 2 may be brain-specific.
Top Pathways Lysosome

Human NAGPA protein fragment - ab162442 from Abcam

Category Protein
Source Wheat germ
Species Human
ab162442 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Recombinant Human NAGPA Protein - H00051172-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

NAGPA - H00051172-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

NAGPA - H00051172-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

NAGPA fusion protein - ag13511 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human NAGPA - NAGPA-867H from Creative Biomart

Category Protein
Source Mammalian Cells
Species Human

Recombinant Human N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase(NAGPA) - CSB-YP015417HU CSB-EP015417HU CSB-BP015417HU CSB-MP015417HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

NAGPA - TP318271 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAGPA)

NAGPA Recombinant Protein Antigen - NBP2-38041PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

NAGPA Peptide, Human - M34GP10105H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAGPA), Recombinant Protein - MBS1453464 from MyBioSource

Category Protein
Prices $770.00, $770.00, $995.00, $995.00, $1,065.00, $1,065.00, $1,525.00, $1,525.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

Recombinant Human NAGPA Protein, MYC/DDK-tagged - NAGPA-189H from Creative Biomart

Category Protein
Source HEK293
Species Human
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