Gene Symbol | MRGPRX1 |
---|---|
Entrez Gene | 259249 |
Alt Symbol | GPCR, MGRG2, MRGX1, SNSR4 |
Species | Human |
Gene Type | protein-coding |
Description | MAS-related GPR, member X1 |
Other Description | G protein-coupled receptor MRGX1|G protein-coupled receptor SNSR3|Mas-related G protein-coupled receptor G2|mas-related G-protein coupled receptor member X1|sensory neuron-specific G-protein coupled receptor 3/4 |
Swissprots | Q8TDD9 Q8TDD8 Q4V9L2 Q96LB2 |
Accessions | AAK91804 AAL86880 AAL86881 ACG60652 BAB89341 BAC06064 CDG86188 EAW68360 Q96LB2 BC096835 AAH96835 NM_147199 NP_671732 |
Function | Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine- induced itch, in a histamine-independent manner. {ECO:0000269|PubMed:11850634, ECO:0000269|PubMed:20004959}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. {ECO:0000269|PubMed:11850634}. |
Lysophosphatidic Acid Receptor 3 (LPAR3), Human, ELISA Kit - SEF543Hu from ARP American Research Products
|
||||||||||
Mas-related G-protein coupled receptor member X4 (MRGPRX4), Human, ELISA Kit - CSB-EL014798HU from ARP American Research Products
|
||||||||||
Human GPCR ELISA Kit - HG0026 from NeoScientific
|
||||||||||
MAS-related GPR, member X1, ELISA Kit - MBS9339051 from MyBioSource
|
||||||||||
Human G Protein Coupled Receptor ELISA - E01G0019 from BlueGene Biotech
|
||||||||||
ELISA Kit for Lysophosphatidic Acid Receptor 3 (LPAR3) - SEF543Hu from Cloud-clone
|
||||||||||
Human GPCR ELISA Kit - E015767 from Biobool
|
||||||||||
Human MRGPRX1 ELISA Kit - E023677 from Biobool
|
||||||||||
Human GPCR ELISA Kit - EHG0026 from ABclonal
|