MRGPRX1

Gene Symbol MRGPRX1
Entrez Gene 259249
Alt Symbol GPCR, MGRG2, MRGX1, SNSR4
Species Human
Gene Type protein-coding
Description MAS-related GPR, member X1
Other Description G protein-coupled receptor MRGX1|G protein-coupled receptor SNSR3|Mas-related G protein-coupled receptor G2|mas-related G-protein coupled receptor member X1|sensory neuron-specific G-protein coupled receptor 3/4
Swissprots Q8TDD9 Q8TDD8 Q4V9L2 Q96LB2
Accessions AAK91804 AAL86880 AAL86881 ACG60652 BAB89341 BAC06064 CDG86188 EAW68360 Q96LB2 BC096835 AAH96835 NM_147199 NP_671732
Function Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine- induced itch, in a histamine-independent manner. {ECO:0000269|PubMed:11850634, ECO:0000269|PubMed:20004959}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. {ECO:0000269|PubMed:11850634}.

MRGX1 CRISPR/Cas9 KO Plasmid (h) - sc-415263 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRGX1 HDR Plasmid (h) - sc-415263-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRGX1 Double Nickase Plasmid (h) - sc-415263-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRGX1 Double Nickase Plasmid (h2) - sc-415263-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRGX1 CRISPR Activation Plasmid (h) - sc-415263-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRGX1 CRISPR Activation Plasmid (h2) - sc-415263-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRGX1 Lentiviral Activation Particles (h) - sc-415263-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRGX1 Lentiviral Activation Particles (h2) - sc-415263-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRGX1 siRNA (h) - sc-106239 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRGX1 shRNA Plasmid (h) - sc-106239-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRGX1 shRNA (h) Lentiviral Particles - sc-106239-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRGX1 RNAi - H00259249-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN14536 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14536 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MRGPRX1 siRNA (Human) - CRJ6806 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MRGPRX1 (NM_147199.3) - SHH344412 from Creative biogene

Category siRNA
Species Reactivities Human

Human MRGPRX1 siRNA - orb277307 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MRGPRX1 shRNA Plasmid (Human) - CHJ6806 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MRGPRX1 miRNA 3'UTR clone - MiUTR1H-06420 from Creative biogene

Species Reactivities Human
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