| Gene Symbol |
MRGPRX1
|
| Entrez Gene |
259249
|
| Alt Symbol |
GPCR, MGRG2, MRGX1, SNSR4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MAS-related GPR, member X1
|
| Other Description |
G protein-coupled receptor MRGX1|G protein-coupled receptor SNSR3|Mas-related G protein-coupled receptor G2|mas-related G-protein coupled receptor member X1|sensory neuron-specific G-protein coupled receptor 3/4
|
| Swissprots |
Q8TDD9 Q8TDD8 Q4V9L2 Q96LB2
|
| Accessions |
AAK91804 AAL86880 AAL86881 ACG60652 BAB89341 BAC06064 CDG86188 EAW68360 Q96LB2 BC096835 AAH96835 NM_147199 NP_671732
|
| Function |
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine- induced itch, in a histamine-independent manner. {ECO:0000269|PubMed:11850634, ECO:0000269|PubMed:20004959}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. {ECO:0000269|PubMed:11850634}.
|