RRAGA

Gene Symbol RRAGA
Entrez Gene 10670
Alt Symbol FIP-1, FIP1, RAGA
Species Human
Gene Type protein-coding
Description Ras-related GTP binding A
Other Description adenovirus E3 14.7 kDa-interacting protein 1|adenovirus E3-14.7K interacting protein 1|rag A|ras-related GTP-binding protein A
Swissprots O00290 B2R7L1 Q15347 Q7L523
Accessions EAW58653 Q7L523 AK313023 BAG35858 BC006433 AAH06433 BC009990 AAH09990 BX346838 BX442654 U41654 AAB63255 X90529 CAA62131 NM_006570 NP_006561
Function Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:8995684, ECO:0000269|PubMed:9394008}.
Subcellular Location Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane.
Tissue Specificity Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain. {ECO:0000269|PubMed:8995684}.
Top Pathways mTOR signaling pathway

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Category ELISA Kit

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Category ELISA Kit
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Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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Category ELISA Kit
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Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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