| Gene Symbol | RRAGA |
|---|---|
| Entrez Gene | 10670 |
| Alt Symbol | FIP-1, FIP1, RAGA |
| Species | Human |
| Gene Type | protein-coding |
| Description | Ras-related GTP binding A |
| Other Description | adenovirus E3 14.7 kDa-interacting protein 1|adenovirus E3-14.7K interacting protein 1|rag A|ras-related GTP-binding protein A |
| Swissprots | O00290 B2R7L1 Q15347 Q7L523 |
| Accessions | EAW58653 Q7L523 AK313023 BAG35858 BC006433 AAH06433 BC009990 AAH09990 BX346838 BX442654 U41654 AAB63255 X90529 CAA62131 NM_006570 NP_006561 |
| Function | Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:8995684, ECO:0000269|PubMed:9394008}. |
| Subcellular Location | Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane. |
| Tissue Specificity | Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain. {ECO:0000269|PubMed:8995684}. |
| Top Pathways | mTOR signaling pathway |