| Gene Symbol | RRAGA |
|---|---|
| Entrez Gene | 10670 |
| Alt Symbol | FIP-1, FIP1, RAGA |
| Species | Human |
| Gene Type | protein-coding |
| Description | Ras-related GTP binding A |
| Other Description | adenovirus E3 14.7 kDa-interacting protein 1|adenovirus E3-14.7K interacting protein 1|rag A|ras-related GTP-binding protein A |
| Swissprots | O00290 B2R7L1 Q15347 Q7L523 |
| Accessions | EAW58653 Q7L523 AK313023 BAG35858 BC006433 AAH06433 BC009990 AAH09990 BX346838 BX442654 U41654 AAB63255 X90529 CAA62131 NM_006570 NP_006561 |
| Function | Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:8995684, ECO:0000269|PubMed:9394008}. |
| Subcellular Location | Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane. |
| Tissue Specificity | Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain. {ECO:0000269|PubMed:8995684}. |
| Top Pathways | mTOR signaling pathway |
Rag A CRISPR/Cas9 KO Plasmid (h) - sc-411501 from Santa Cruz Biotechnology
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Rag A HDR Plasmid (h) - sc-411501-HDR from Santa Cruz Biotechnology
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Rag A Double Nickase Plasmid (h) - sc-411501-NIC from Santa Cruz Biotechnology
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Rag A Double Nickase Plasmid (h2) - sc-411501-NIC-2 from Santa Cruz Biotechnology
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Rag A CRISPR Activation Plasmid (h) - sc-411501-ACT from Santa Cruz Biotechnology
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Rag A CRISPR Activation Plasmid (h2) - sc-411501-ACT-2 from Santa Cruz Biotechnology
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Rag A Lentiviral Activation Particles (h) - sc-411501-LAC from Santa Cruz Biotechnology
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Rag A Lentiviral Activation Particles (h2) - sc-411501-LAC-2 from Santa Cruz Biotechnology
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Rag A siRNA (h) - sc-92670 from Santa Cruz Biotechnology
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Rag A shRNA Plasmid (h) - sc-92670-SH from Santa Cruz Biotechnology
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Rag A shRNA (h) Lentiviral Particles - sc-92670-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU051591 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18676 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18676 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04688 from Sigma-Aldrich
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RRAGA siRNA (Human) - CRH7277 from Cohesion Biosciences
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RRAGA - MBS8235935 from MyBioSource
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shRNA set against Human RRAGA (NM_006570.4) - SHH399844 from Creative biogene
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shRNA set against Human RRAGA(NM_006570.4) - SHR199104 from Creative biogene
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Human RRAGA siRNA - orb267779 from Biorbyt
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RRAGA shRNA Plasmid (Human) - CHH7277 from Cohesion Biosciences
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RRAGA miRNA 3'UTR clone - MiUTR1H-09040 from Creative biogene
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