RRAGA

Gene Symbol	RRAGA
Entrez Gene	10670
Alt Symbol	FIP-1, FIP1, RAGA
Species	Human
Gene Type	protein-coding
Description	Ras-related GTP binding A
Other Description	adenovirus E3 14.7 kDa-interacting protein 1|adenovirus E3-14.7K interacting protein 1|rag A|ras-related GTP-binding protein A
Swissprots	O00290 B2R7L1 Q15347 Q7L523
Accessions	EAW58653 Q7L523 AK313023 BAG35858 BC006433 AAH06433 BC009990 AAH09990 BX346838 BX442654 U41654 AAB63255 X90529 CAA62131 NM_006570 NP_006561
Function	Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:8995684, ECO:0000269|PubMed:9394008}.
Subcellular Location	Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane.
Tissue Specificity	Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain. {ECO:0000269|PubMed:8995684}.
Top Pathways	mTOR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RRAGA + RRAGB peptide - ab91427 from Abcam Category Peptide

Human RRAGA + RRAGB peptide - ab91638 from Abcam Category Peptide

Human RRAGA full length protein - ab161103 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human RRAGA Protein - H00010670-P01 from Novus Biologicals Category Protein Prices $305.00, $445.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Human RAGA protein - orb245177 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

RRAGA / Rag A - H00010670-P01-02 from Acris Antibodies Category Protein Prices $300.00 Sizes 2 µg Source in vitro transl. Species Human

RRAGA fusion protein - ag0952 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant human Ras-related GTP-binding protein A protein - CSB-EP034654h CSB-BP034654h CSB-MP034654h from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Ras-related GTP-binding protein A(RRAGA) - CSB-YP752099HU CSB-EP752099HU CSB-BP752099HU CSB-MP752099HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Ras-related GTP-binding protein A(RRAGA),partial - CSB-RP034654h from Cusabio Category Protein Source E.coli Species Human

RagA/B Blocking Peptide - abx161722 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Monkey

RRAGA Protein - abx163660 from Abbexa Category Protein Species Human, Mouse, Rat

RRAGA / Rag A - TP303493 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RRAGA-Antibody-C-term-Blocking-peptide - BP5772b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RRAGA Peptide, Human - M34GP13617H from Creative Peptides Category Peptide Source Synthetic. Species Human

RagA/B Blocking Peptide - CBP4511 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Monkey

Recombinant human Ras-related GTP-binding protein A - AP71819 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Ras-related GTP-binding protein A, Recombinant Protein - MBS9421651 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli Species Human

Ras-related GTP-binding protein A, Recombinant Protein - MBS717268 from MyBioSource Category Protein Prices $190.00, $460.00, $750.00, $1,180.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 1 mg (E-Coli) Source E Coli

Ras-related GTP-binding protein A (RRAGA), Recombinant Protein - MBS1344422 from MyBioSource Category Protein Prices $1,070.00, $1,070.00, $1,300.00, $1,300.00, $1,675.00, $1,675.00, $2,140.00, $2,140.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RRAGA fusion protein - Ag25872 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

RagA/B Blocking Peptide - orb392856 from Biorbyt Category Peptide Species Bovine, Human, Mouse, Rat, Monkey

Recombinant Human RRAGA Protein (1-247 aa), GST-tagged - RRAGA-1197H from Creative Biomart Category Protein Source E. coli Species Human

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