MAX
| Gene Symbol | MAX |
|---|---|
| Entrez Gene | 4149 |
| Alt Symbol | bHLHd4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | MYC associated factor X |
| Other Description | class D basic helix-loop-helix protein 4|protein max |
| Swissprots | A6NH73 P61244 Q14803 Q96CY8 A8K4G4 A8K265 A8K824 |
| Accessions | CAA47337 CAA47338 CAA47339 EAW80898 EAW80899 EAW80900 EAW80901 EAW80902 EAW80903 EAW80904 EAW80905 EAW80906 P61244 AI652319 AI655674 AI769390 AI917842 AI954328 AK290130 BAF82819 AK290929 BAF83618 AK292189 BAF84878 AK292630 BAF85319 AK303412 BAG64465 AL833643 AY353088 AAQ57210 BC003525 AAH03525 BC004516 AAH04516 BC013669 AAH13669 BC025685 AAH25685 BC027924 AAH27924 BC036092 AAH36092 BF038005 BF062526 BG177865 CR542191 CAG46988 DB451269 DB482510 HY018878 JF432558 ADZ15775 M64240 AAA36200 X60287 CAA42827 XM_011536773 XP_011535075 XR_429315 XR_943450 XR_943451 XR_943452 NM_001271068 NP_001257997 NM_001271069 NP_001257998 NM_002382 NP_002373 NM_145112 NP_660087 NM_145113 NP_660088 NM_145114 NP_660089 NM_197957 NP_932061 NR_073137 NR_073138 NM_145116 |
| Function | Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. |
| Subcellular Location | Nucleus. Cell projection, dendrite {ECO:0000250}. |
| Tissue Specificity | High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle. |
| Top Pathways | Small cell lung cancer, MAPK signaling pathway, Transcriptional misregulation in cancer |
Max CRISPR/Cas9 KO Plasmid (h) - sc-400596 from Santa Cruz Biotechnology
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Max HDR Plasmid (h) - sc-400596-HDR from Santa Cruz Biotechnology
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Max Double Nickase Plasmid (h) - sc-400596-NIC from Santa Cruz Biotechnology
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Max Double Nickase Plasmid (h2) - sc-400596-NIC-2 from Santa Cruz Biotechnology
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Max CRISPR Activation Plasmid (h) - sc-400596-ACT from Santa Cruz Biotechnology
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Max CRISPR Activation Plasmid (h2) - sc-400596-ACT-2 from Santa Cruz Biotechnology
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Max Lentiviral Activation Particles (h) - sc-400596-LAC from Santa Cruz Biotechnology
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Max Lentiviral Activation Particles (h2) - sc-400596-LAC-2 from Santa Cruz Biotechnology
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Max siRNA (h) - sc-38079 from Santa Cruz Biotechnology
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Max shRNA Plasmid (h) - sc-38079-SH from Santa Cruz Biotechnology
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Max shRNA (h) Lentiviral Particles - sc-38079-V from Santa Cruz Biotechnology
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Max RNAi - H00004149-R01 from Novus Biologicals
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Max RNAi - H00004149-R02 from Novus Biologicals
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Max RNAi - H00004149-R05 from Novus Biologicals
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Max RNAi - H00004149-R03 from Novus Biologicals
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MISSION® esiRNA - EHU096141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13067 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13067 from Sigma-Aldrich
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MAX siRNA (Human) - CRH2822 from Cohesion Biosciences
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Max RNAi - H00004149-R04 from Novus Biologicals
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Max RNAi - H00004149-R06 from Novus Biologicals
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shRNA set against Human MAX (NM_002382.4) - SHH338695 from Creative biogene
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Human MAX siRNA - orb263324 from Biorbyt
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MAX shRNA Plasmid (Human) - CHH2822 from Cohesion Biosciences
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MAX miRNA 3'UTR clone - MiUTR3H-01384 from Creative biogene
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