LAMTOR1

Gene Symbol	LAMTOR1
Entrez Gene	55004
Alt Symbol	C11orf59, PDRO, Ragulator1, p18, p27RF-Rho
Species	Human
Gene Type	protein-coding
Description	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Other Description	RhoA activator C11orf59|late endosomal/lysosomal adaptor and MAPK and MTOR activator 1|lipid raft adaptor protein p18|p27Kip1-releasing factor from RhoA|p27kip1 releasing factor from RhoA|protein associated with DRMs and endosomes|ragulator complex protein LAMTOR1|ragulator complex protein PDRO
Swissprots	Q9NWT0 Q6IAA8 Q8WZ09
Accessions	EAW74836 EAW74837 Q6IAA8 AF289583 AAL55767 AK000632 BAA91297 AK300681 BAG62364 BC001706 AAH01706 BX381569 CR457247 CAG33528 NM_017907 NP_060377
Function	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation. {ECO:0000269|PubMed:19654316, ECO:0000269|
Subcellular Location	Late endosome membrane; Lipid-anchor; Cytoplasmic side. Lysosome membrane; Lipid-anchor; Cytoplasmic side. Cell membrane.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

LAMTOR1/C11orf59 (D11H6) XP ® Rabbit mAb - 8975 from Cell Signaling Technology Prices $109.00, $277.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D11H6

C11orf59 (S-14) - sc-167255 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

C11orf59 (C-13) - sc-167253 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

C11orf59 (E-15) - sc-167254 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-LAMTOR1 antibody - ab121157 from Abcam Prices $443.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LAMTOR1 antibody - N-terminal - ab181017 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-LAMTOR1 Antibody (aa50-250) - LS-C143599 from LifeSpan Bioscience Prices $335.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-LAMTOR1 Antibody (N-Terminus) - LS-C201197 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

c11orf59/LAMTOR1 Antibody - NBP1-71689 from Novus Biologicals Prices $279.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

c11orf59/LAMTOR1 Antibody - NBP1-89909 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LAMTOR1 Polyclonal Antibody - bs-13687R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LAMTOR1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13687R-A350 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LAMTOR1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-13687R-A488 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LAMTOR1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-13687R-A555 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LAMTOR1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-13687R-A647 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LAMTOR1 Polyclonal Antibody, Cy3 Conjugated - bs-13687R-Cy3 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LAMTOR1 Polyclonal Antibody, Cy5 Conjugated - bs-13687R-Cy5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LAMTOR1 Polyclonal Antibody, Cy5.5 Conjugated - bs-13687R-Cy5.5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LAMTOR1 Polyclonal Antibody, Cy7 Conjugated - bs-13687R-Cy7 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LAMTOR1 Polyclonal Antibody, FITC Conjugated - bs-13687R-FITC from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LAMTOR1 Polyclonal Antibody, Biotin Conjugated - bs-13687R-Biotin from Bioss Prices $349.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LAMTOR1 Polyclonal Antibody, HRP Conjugated - bs-13687R-HRP from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ANTI-LAMTOR1 antibody produced in rabbit - HPA002997 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LAMTOR1 antibody produced in rabbit - SAB3501106 from Sigma-Aldrich Prices $341.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

LAMTOR1 antibody - orb157772 from Biorbyt Prices $255.00, $340.00 Sizes 100 μg, 200 μg Host Rabbit Clonality Polyclonal

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