LAMTOR1

Gene Symbol LAMTOR1
Entrez Gene 55004
Alt Symbol C11orf59, PDRO, Ragulator1, p18, p27RF-Rho
Species Human
Gene Type protein-coding
Description late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Other Description RhoA activator C11orf59|late endosomal/lysosomal adaptor and MAPK and MTOR activator 1|lipid raft adaptor protein p18|p27Kip1-releasing factor from RhoA|p27kip1 releasing factor from RhoA|protein associated with DRMs and endosomes|ragulator complex protein LAMTOR1|ragulator complex protein PDRO
Swissprots Q9NWT0 Q6IAA8 Q8WZ09
Accessions EAW74836 EAW74837 Q6IAA8 AF289583 AAL55767 AK000632 BAA91297 AK300681 BAG62364 BC001706 AAH01706 BX381569 CR457247 CAG33528 NM_017907 NP_060377
Function As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation. {ECO:0000269|PubMed:19654316, ECO:0000269|
Subcellular Location Late endosome membrane; Lipid-anchor; Cytoplasmic side. Lysosome membrane; Lipid-anchor; Cytoplasmic side. Cell membrane.

C11orf59-Antibody-N-term-Blocking-peptide - BP13455a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

LAMTOR1 Peptide - 7709P from ProSci

Category Peptide
Species Human

Recombinant Human Ragulator complex protein LAMTOR1(LAMTOR1) - CSB-YP757083HU CSB-EP757083HU CSB-BP757083HU CSB-MP757083HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

c11orf59/LAMTOR1 Recombinant Protein Antigen - NBP1-89909PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

LAMTOR1 Peptide, Human - M34GP08535H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

LAMTOR1 Recombinant Protein (OPCA03625) - OPCA03625 from Aviva Systems Biology

Category Protein
Prices $365.00
Sizes 50 µg
Source Human

Recombinant Human Ragulator complex protein LAMTOR1(LAMTOR1) - AP74445 from Signalway Antibody

Category Protein
Prices $155.00, $390.00, $665.00, $1,090.00, $1,835.00, $2,915.00
Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg
Source E.coli
Species Human

Ragulator complex protein LAMTOR1, Recombinant Protein - MBS1443133 from MyBioSource

Category Protein
Prices $135.00, $255.00, $665.00, $900.00, $1,090.00, $1,125.00, $1,125.00, $1,330.00, $1,710.00, $1,785.00, $1,785.00
Sizes 10 µg (E-Coli), 50 µg (E-Coli), 200 µg (E-Coli), 50 µg (Baculovirus), 500 µg (E-Coli), 50 µg (Mammalian-Cell), 500 µg (Yeast), 100 µg (Baculovirus), 1 mg (E-Coli), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

Ragulator complex protein LAMTOR1 (LAMTOR1), Recombinant Protein - MBS9424025 from MyBioSource

Category Protein
Prices $200.00, $380.00, $610.00, $960.00, $1,570.00
Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg
Source E Coli
Species Human

Human LAMTOR1 protein - orb358894 from Biorbyt

Category Protein
Species Human

Recombinant Human LAMTOR1 Protein (2-161 aa), His-tagged - LAMTOR1-2000H from Creative Biomart

Category Protein
Source E. coli
Species Human
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