| Gene Symbol | LAMTOR1 |
|---|---|
| Entrez Gene | 55004 |
| Alt Symbol | C11orf59, PDRO, Ragulator1, p18, p27RF-Rho |
| Species | Human |
| Gene Type | protein-coding |
| Description | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 |
| Other Description | RhoA activator C11orf59|late endosomal/lysosomal adaptor and MAPK and MTOR activator 1|lipid raft adaptor protein p18|p27Kip1-releasing factor from RhoA|p27kip1 releasing factor from RhoA|protein associated with DRMs and endosomes|ragulator complex protein LAMTOR1|ragulator complex protein PDRO |
| Swissprots | Q9NWT0 Q6IAA8 Q8WZ09 |
| Accessions | EAW74836 EAW74837 Q6IAA8 AF289583 AAL55767 AK000632 BAA91297 AK300681 BAG62364 BC001706 AAH01706 BX381569 CR457247 CAG33528 NM_017907 NP_060377 |
| Function | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation. {ECO:0000269|PubMed:19654316, ECO:0000269| |
| Subcellular Location | Late endosome membrane; Lipid-anchor; Cytoplasmic side. Lysosome membrane; Lipid-anchor; Cytoplasmic side. Cell membrane. |