RPS6KA5
| Gene Symbol | RPS6KA5 |
|---|---|
| Entrez Gene | 9252 |
| Alt Symbol | MSK1, MSPK1, RLPK |
| Species | Human |
| Gene Type | protein-coding |
| Description | ribosomal protein S6 kinase, 90kDa, polypeptide 5 |
| Other Description | 90 kDa ribosomal protein S6 kinase 5|RSK-like protein kinase|RSKL|S6K-alpha-5|nuclear mitogen- and stress-activated protein kinase 1|ribosomal protein S6 kinase alpha-5 |
| Swissprots | O95316 O75582 B7Z2Y5 Q96AF7 |
| Accessions | EAW81439 EAW81440 O75582 AF074393 AAC31171 AF080000 AAD23915 AF090421 AAC69577 AK295266 BAH12021 AK309925 AL050099 CAB43270 BC017187 AAH17187 BF593074 BG699153 XM_011537360 XP_011535662 NM_004755 NP_004746 NM_182398 NP_872198 |
| Function | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phos |
| Subcellular Location | Nucleus. Cytoplasm. Note=Predominantly nuclear. Exported into cytoplasm in response to glucocorticoid. |
| Tissue Specificity | Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver. {ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
| Top Pathways | Bladder cancer, MAPK signaling pathway, Neurotrophin signaling pathway, Circadian entrainment, TNF signaling pathway |
Mouse/Human Phospho-RPS6KA5 / MSK1 (Thr581) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1261 from LifeSpan Bioscience
|
||||||||
Mouse/Human Phospho-RPS6KA5 / MSK1 (Ser212) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1690 from LifeSpan Bioscience
|
||||||||
Mouse/Human Phospho-RPS6KA5 / MSK1 (Ser376) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1568 from LifeSpan Bioscience
|
||||||||
Mouse/Human RPS6KA5 / MSK1 ELISA Kit (Cell-Based ELISA) - LS-F2170 from LifeSpan Bioscience
|
||||||||
Ribosomal protein S6 kinase alpha-5 (RPS6KA5), Human, ELISA Kit - E01R0422 from ARP American Research Products
|
||||||||
RPS6KA5 (Human) Matched Antibody Pair - H00009252-AP11 from Acris Antibodies
|
||||||||
MSK1 Colorimetric Cell-Based ELISA Kit - CB5471 from Assay Biotechnology
|
||||||||
MSK1 (Phospho-Thr581) Colorimetric Cell-Based ELISA Kit - CBP1261 from Assay Biotechnology
|
||||||||
MSK1 (Phospho-Ser376) Colorimetric Cell-Based ELISA Kit - CBP1619 from Assay Biotechnology
|
||||||||
MSK1 (Phospho-Ser212) Colorimetric Cell-Based ELISA Kit - CBP1757 from Assay Biotechnology
|
||||||||
Ribosomal protein S6 kinase Alpha 5 (RPS6KA5), ELISA Kit - MBS7248854 from MyBioSource
|
||||||||
Ribosomal protein S6 kinase Alpha 5 (RPS6KA5), ELISA Kit - MBS7218662 from MyBioSource
|
||||||||
Ribosomal protein S6 kinase alpha-5 (RPS6KA5), ELISA Kit - MBS7247439 from MyBioSource
|
||||||||
Ribosomal protein S6 kinase alpha-5 (RPS6KA5), ELISA Kit - MBS7215203 from MyBioSource
|
||||||||
Ribosomal protein S6 kinase alpha-5 (RPS6KA5), ELISA Kit - MBS7214472 from MyBioSource
|
||||||||
Ribosomal protein S6 kinase alpha-5 (RPS6KA5), ELISA Kit - MBS7226518 from MyBioSource
|
||||||||
Ribosomal protein S6 kinase alpha-5 (RPS6KA5), ELISA Kit - MBS7213983 from MyBioSource
|
||||||||
Ribosomal protein S6 kinase alpha-5 (RPS6KA5), ELISA Kit - MBS7237546 from MyBioSource
|
||||||||
Ribosomal protein S6 kinase alpha-5 (RPS6KA5), ELISA Kit - MBS7210982 from MyBioSource
|
||||||||
Ribosomal protein S6 kinase alpha-5 (RPS6KA5), ELISA Kit - MBS7237863 from MyBioSource
|
||||||||
Ribosomal protein S6 kinase alpha-5 (RPS6KA5), ELISA Kit - MBS7238647 from MyBioSource
|
||||||||
Human Phospho-MSK1 (S376) ELISA - PEL-MSK1-S376 from RayBiotech
|
||||||||
Human Phospho-MSK1 (S376) & Total MSK1 ELISA - PEL-MSK1-S376-T from RayBiotech
|
||||||||
MSK1 ELISA Kit - DEIA-XYA1895 from Creative Diagnostics
|
||||||||
MSK1 (Phospho-Ser212) ELISA Kit - DEIA-XYA1896 from Creative Diagnostics
|