| Gene Symbol | RPS6KA5 |
|---|---|
| Entrez Gene | 9252 |
| Alt Symbol | MSK1, MSPK1, RLPK |
| Species | Human |
| Gene Type | protein-coding |
| Description | ribosomal protein S6 kinase, 90kDa, polypeptide 5 |
| Other Description | 90 kDa ribosomal protein S6 kinase 5|RSK-like protein kinase|RSKL|S6K-alpha-5|nuclear mitogen- and stress-activated protein kinase 1|ribosomal protein S6 kinase alpha-5 |
| Swissprots | O95316 O75582 B7Z2Y5 Q96AF7 |
| Accessions | EAW81439 EAW81440 O75582 AF074393 AAC31171 AF080000 AAD23915 AF090421 AAC69577 AK295266 BAH12021 AK309925 AL050099 CAB43270 BC017187 AAH17187 BF593074 BG699153 XM_011537360 XP_011535662 NM_004755 NP_004746 NM_182398 NP_872198 |
| Function | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phos |
| Subcellular Location | Nucleus. Cytoplasm. Note=Predominantly nuclear. Exported into cytoplasm in response to glucocorticoid. |
| Tissue Specificity | Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver. {ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
| Top Pathways | Bladder cancer, MAPK signaling pathway, Neurotrophin signaling pathway, Circadian entrainment, TNF signaling pathway |