RPS6KA5

Gene Symbol	RPS6KA5
Entrez Gene	9252
Alt Symbol	MSK1, MSPK1, RLPK
Species	Human
Gene Type	protein-coding
Description	ribosomal protein S6 kinase, 90kDa, polypeptide 5
Other Description	90 kDa ribosomal protein S6 kinase 5|RSK-like protein kinase|RSKL|S6K-alpha-5|nuclear mitogen- and stress-activated protein kinase 1|ribosomal protein S6 kinase alpha-5
Swissprots	O95316 O75582 B7Z2Y5 Q96AF7
Accessions	EAW81439 EAW81440 O75582 AF074393 AAC31171 AF080000 AAD23915 AF090421 AAC69577 AK295266 BAH12021 AK309925 AL050099 CAB43270 BC017187 AAH17187 BF593074 BG699153 XM_011537360 XP_011535662 NM_004755 NP_004746 NM_182398 NP_872198
Function	Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phos
Subcellular Location	Nucleus. Cytoplasm. Note=Predominantly nuclear. Exported into cytoplasm in response to glucocorticoid.
Tissue Specificity	Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver. {ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}.
Top Pathways	Bladder cancer, MAPK signaling pathway, Neurotrophin signaling pathway, Circadian entrainment, TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MSK1 full length protein - ab84805 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Human MSK1 full length protein - ab152964 from Abcam Category Protein Source Wheat germ Species Human

Human MSK1 protein fragment - ab152965 from Abcam Category Protein Source Wheat germ Species Human

Human MSK1 protein fragment - ab152966 from Abcam Category Protein Source Wheat germ Species Human

MSK1/RPS6KA5 Recombinant Protein - H00009252-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human MSK1/RPS6KA5 Protein - H00009252-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MSK1/RPS6KA5 Partial Recombinant Protein - H00009252-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MSK1-Antibody-Center-Blocking-Peptide - BP7010c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MSK1 (phospho-Thr581) Blocking Peptide - abx063570 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Dog, Monkey, Pig, Rabbit

RPS6KA5 / MSK1 - H00009252-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RPS6KA5 / MSK1 - H00009252-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RPS6KA5 / MSK1 - H00009252-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RPS6KA5 / MSK1 - H00009252-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RPS6KA5 / MSK1 - H00009252-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

RPS6KA5 / MSK1 - H00009252-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RPS6KA5 / MSK1 - H00009252-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RPS6KA5 fusion protein - Ag8837 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

RPS6KA5 fusion protein - Ag8765 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human RPS6KA5, GST-tagged, Active - RPS6KA5-359H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human RPS6KA5 - RPS6KA5-30250TH from Creative Biomart Category Protein

Recombinant Human RPS6KA5, His-tagged - RPS6KA5-2435H from Creative Biomart Category Protein Source E.coli Species Human

MSK1 Protein, active, 250 µg - 14-548M from EMD Millipore Category Protein Prices $2,543.00 Sizes 250 µg also available in 10 μg size . (cat#14-548) and in bulk (cat# 14-548-K) Source Expressed by baculovirus in Sf21 insect cells

MSK1 Protein, active, 10 µg - 14-548 from EMD Millipore Category Protein Prices $401.00 Sizes 10 µg also available in 250 µg size --call for pricing and availability and reference catalog numbe Source Expressed by baculovirus in Sf21 insect cells

MSK1 (pT581) Blocking Peptide - CBP2376 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Chicken, Dog, Monkey, Pig, Rabbit

p-MSK1(Thr581) Peptide - AP0095P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Search more