| Gene Symbol |
G2E3
|
| Entrez Gene |
55632
|
| Alt Symbol |
KIAA1333, PHF7B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G2/M-phase specific E3 ubiquitin protein ligase
|
| Other Description |
G2/M phase-specific E3 ubiquitin-protein ligase|G2/M-phase specific E3 ubiquitin ligase|PHD finger protein 7B
|
| Swissprots |
Q9NXC0 Q9BVR2 Q9P2L3 Q9H9E9 Q7L622
|
| Accessions |
EAW65969 Q7L622 AB037754 BAA92571 AI432917 AK000340 BAA91095 AK022867 BAB14280 AK093536 AK225346 AK295571 BAG58471 AK296872 BAG59435 AW963891 BC000973 AAH00973 BC008436 BC040179 AAH40179 BM993069 DA491192 XM_005267836 XP_005267893 XM_011536925 XP_011535227 XM_011536926 XP_011535228 XM_011536927 XP_011535229 XM_011536928 XP_011535230 XM_011536929 XP_011535231 NM_001308097 NP_001295026 NM_017769 NP_060239
|
| Function |
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death. {ECO:0000269|PubMed:18511420}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:17239372}. Cytoplasm {ECO:0000269|PubMed:17239372}. Note=Shuttles between the nucleus and the cytoplasm. In the nucleus, delocalizes from the nucleolus to the nucleoplasm in response to DNA damage.
|
| Tissue Specificity |
Predominantly expressed in brain, liver, kidney, testes and ovary. {ECO:0000269|PubMed:10718198}.
|