| Gene Symbol |
PAPOLA
|
| Entrez Gene |
10914
|
| Alt Symbol |
PAP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
poly(A) polymerase alpha
|
| Other Description |
PAP-alpha|polynucleotide adenylyltransferase alpha
|
| Swissprots |
Q9BVU2 Q86TV0 P51003 Q8IYF5 Q86SX4
|
| Accessions |
EAW81642 EAW81643 EAW81644 EAW81645 EAW81646 EAW81647 EAW81648 EAW81649 P51003 AA236200 AF002990 AK024849 AK057629 AK097832 AK295020 BAG58079 AK302406 BAG63716 AK302984 BAG64124 AK303402 BAG64456 AK307659 AK307680 AK316168 BAH14539 BC000927 AAH00927 BC015150 BC036014 AAH36014 BX089817 BX161482 CAD61935 BX248301 CAD62628 BX248753 CAD66560 CD655865 DB045100 DB483858 X76770 XM_005267281 XP_005267338 XM_005267282 XP_005267339 NM_001252006 NP_001238935 NM_001252007 NP_001238936 NM_001293627 NP_001280556 NM_001293628 NP_001280557 NM_001293632 NP_001280561 NM_032632 NP_116021
|
| Function |
Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=The 90 kDa form is nuclear while the 100 kDa and the 106 kDa forms are both nuclear and cytoplasmic.
|
| Top Pathways |
mRNA surveillance pathway
|