TRIM24

Gene Symbol TRIM24
Entrez Gene 8805
Alt Symbol PTC6, RNF82, TF1A, TIF1, TIF1A, TIF1ALPHA, hTIF1
Species Human
Gene Type protein-coding
Description tripartite motif containing 24
Other Description E3 ubiquitin-protein ligase TRIM24|RING finger protein 82|TIF1-alpha|transcription intermediary factor 1-alpha|transcriptional intermediary factor 1|tripartite motif-containing 24
Swissprots O95854 A4D1R8 O15164 A4D1R7
Accessions CAF86917 CBJ56868 EAL24046 EAL24047 EAW83884 EAW83885 EAW83886 O15164 AA844662 AF009353 AAB63585 AF119042 AAD17258 AK075306 BAG52105 AK302679 BAG63911 AK312610 AL360186 BC028689 AAH28689 CB988362 XM_011516650 XP_011514952 NM_003852 NP_003843 NM_015905 NP_056989
Function Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000269|PubMed:21164480}. Cytoplasm {ECO:0000269|PubMed:21164480}. Note=Colocalizes with sites of active transcription. Detected both in nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear.

TIF1α (C-4) - sc-271266 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TIF1α (C-4): sc-271266. Western blot analysis of TIF1α expression in IMR-32 whole cell lysate (A) and HeLa nuclear extract (B).

TIF1α (L-15) - sc-15257 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TIF1α (H-190) - sc-33185 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TIF1α (H-190): sc-33185. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

TIF1α (C-18) - sc-15258 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-TIF1 alpha antibody - ab70560 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling TIF1 alpha with ab70560 at 1/1000 (0.2µg/ml). Detection: DAB.

Anti-TIF1 alpha antibody - ab167089 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-TIF1 alpha antibody (ab167089) at 0.5 µg/mlLane 2 : Anti-TIF1 alpha antibody (ab167089) at 1 µg/mlLane 1 : mouse EL4 cell lysateLane 2 : mouse EL4 cell lysateLysates/proteins at 15 µg per lane.

Anti-TIF1 alpha antibody - ab57994 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
TIF1 alpha antibody (ab57994) used in immunohistochemistry at 6ug/ml on formalin fixed and paraffin embedded human testis.

Anti-TIF1 alpha antibody - ab84381 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human breast tumor tissue using 1/250 ab84381, followed by DAB staining.

Anti-TIF1 alpha antibody - ab137194 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TIF1 alpha antibody (ab137194) at 1/500 dilution + HepG2 cell lysate at 30 µg

Anti-TIF1 alpha antibody - ab38264 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ab38264 (4µg/ml) staining of paraffin embedded Human Breast cancer. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. Shows nuclear staining in the distorted lobules.

Anti-TIF1 alpha antibody - ab138732 from Abcam

Prices $370.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue labelling TIF1 alpha using ab138732 at 4µg/ml.

Anti-TIF1 alpha antibody [EPR6102] - ab174287 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6102
All lanes : Anti-TIF1 alpha antibody [EPR6102] (ab174287) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : 293T cell lysateLane 3 : MCF7 cell lysateLysates/proteins at 10 µg per lane.

Anti-TRIM24 / TIF1 Antibody (aa706-1016, clone 2D9) - LS-C336687 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D9
IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-TRIM24 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-TRIM24 / TIF1 Antibody (C-Terminus) - LS-C110265 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TRIM24 antibody LS-C110265 Western blot of PANC1 cell lysate.

Anti-TRIM24 / TIF1 Antibody (aa503-552) - LS-C109913 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TRIM24 antibody LS-C109913 Western blot of HeLa lysate.

Anti-TRIM24 / TIF1 Antibody - LS-C155265 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: HeLa 5% SDS PAGE TRIM24 antibody diluted at 1:1000

Anti-TRIM24 / TIF1 Antibody (aa16-45, AP) - LS-C272180 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM24 / TIF1 Antibody (aa16-45, APC) - LS-C272181 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM24 / TIF1 Antibody (aa16-45) - LS-C157270 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TRIM24 Antibody ( N-term) western blot of U-937,mouse NIH/3T3 cell line lysates (35 ug/lane). The TRIM24 antibody detected the TRIM24 protein (arrow).

Anti-TRIM24 / TIF1 Antibody (aa16-45, Biotin) - LS-C272182 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM24 / TIF1 Antibody (aa16-45, FITC) - LS-C272183 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM24 / TIF1 Antibody (aa16-45, PE) - LS-C272185 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM24 / TIF1 Antibody (aa16-45, Azide-free, HRP) - LS-C272184 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM24 / TIF1 Antibody (C-Terminus) - LS-C287673 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM24 / TIF1 Antibody (aa15-45) - LS-C325937 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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