TRIM24

Gene Symbol	TRIM24
Entrez Gene	8805
Alt Symbol	PTC6, RNF82, TF1A, TIF1, TIF1A, TIF1ALPHA, hTIF1
Species	Human
Gene Type	protein-coding
Description	tripartite motif containing 24
Other Description	E3 ubiquitin-protein ligase TRIM24|RING finger protein 82|TIF1-alpha|transcription intermediary factor 1-alpha|transcriptional intermediary factor 1|tripartite motif-containing 24
Swissprots	O95854 A4D1R8 O15164 A4D1R7
Accessions	CAF86917 CBJ56868 EAL24046 EAL24047 EAW83884 EAW83885 EAW83886 O15164 AA844662 AF009353 AAB63585 AF119042 AAD17258 AK075306 BAG52105 AK302679 BAG63911 AK312610 AL360186 BC028689 AAH28689 CB988362 XM_011516650 XP_011514952 NM_003852 NP_003843 NM_015905 NP_056989
Function	Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:21164480}. Cytoplasm {ECO:0000269|PubMed:21164480}. Note=Colocalizes with sites of active transcription. Detected both in nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TIF1 alpha full length protein - ab132252 from Abcam Category Protein Source Wheat germ Species Human

Human TIF1 alpha peptide - ab45496 from Abcam Category Peptide Species Human

Human TIF1 alpha protein fragment - ab160203 from Abcam Category Protein Source Wheat germ Species Human

Human TIF1 alpha protein fragment - ab176928 from Abcam Category Protein Source E. coli Species Human

TRIM24 / TIF1 Antibody Blocking Peptide - LS-E5588 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM24 / TIF1 Antibody Blocking Peptide - LS-E25484 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM24 / TIF1 Antibody Blocking Peptide - LS-E12210 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM24 / TIF1 Antibody Blocking Peptide - LS-E31448 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TRIM24 / TIF1 Antibody Blocking Peptide - LS-E13790 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TIF1 alpha Protein - H00008805-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human TIF1 alpha Protein - H00008805-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TRIM24-Antibody-N-term-Blocking-Peptide - BP18114a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TIF1 alpha blocking peptide - GTX89729-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Bovine

TIF1 alpha Peptide - AC21-0313-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TIF1-alpha / TRIM24 - H00008805-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

TIF1-alpha / TRIM24 - H00008805-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

TIF1-alpha / TRIM24 - H00008805-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TIF1-alpha / TRIM24 - H00008805-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TIF1 alpha Peptide - 46-493P from ProSci Category Peptide Species Human

TRIM24 Peptide - 7383P from ProSci Category Peptide Species Human

TRIM24 fusion protein - Ag5417 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, T-HIS Species Human

Recombinant TRIM24 (862-980) protein - 31368 from ActiveMotif Category Protein Prices $395.00, $3,500.00 Sizes 100 µg, 1 mg Source E. coli Species Human

Recombinant Human TRIM24, GST-tagged - TRIM24-166H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human TRIM24, His-tagged - TRIM24-3409H from Creative Biomart Category Protein Source E.coli Species Human

TIF1 alpha Blocking Peptide - CBP2324 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Bovine, Dog, Monkey, Pig

Search more