| Gene Symbol |
TRIM24
|
| Entrez Gene |
8805
|
| Alt Symbol |
PTC6, RNF82, TF1A, TIF1, TIF1A, TIF1ALPHA, hTIF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tripartite motif containing 24
|
| Other Description |
E3 ubiquitin-protein ligase TRIM24|RING finger protein 82|TIF1-alpha|transcription intermediary factor 1-alpha|transcriptional intermediary factor 1|tripartite motif-containing 24
|
| Swissprots |
O95854 A4D1R8 O15164 A4D1R7
|
| Accessions |
CAF86917 CBJ56868 EAL24046 EAL24047 EAW83884 EAW83885 EAW83886 O15164 AA844662 AF009353 AAB63585 AF119042 AAD17258 AK075306 BAG52105 AK302679 BAG63911 AK312610 AL360186 BC028689 AAH28689 CB988362 XM_011516650 XP_011514952 NM_003852 NP_003843 NM_015905 NP_056989
|
| Function |
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:21164480}. Cytoplasm {ECO:0000269|PubMed:21164480}. Note=Colocalizes with sites of active transcription. Detected both in nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear.
|