Casp3
| Gene Symbol | Casp3 |
|---|---|
| Entrez Gene | 25402 |
| Alt Symbol | Lice |
| Species | Rat |
| Gene Type | protein-coding |
| Description | caspase 3 |
| Other Description | CASP-3|CPP-32|CPP32beta|Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease)|Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease)|IRP|SCA-1|SREBP cleavage activity 1|apopain|caspase-3|cysteine protease CPP32|protein Yama|yama protein |
| Swissprots | Q62993 P70543 P97699 P55213 |
| Accessions | EDL78892 EDL78893 EDL78894 P55213 BC081854 AAH81854 U34685 AAC52261 U49930 AAC52765 U84410 AAB41792 XM_006253130 XP_006253192 NM_012922 NP_037054 |
| Function | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Expressed in heart, brain, liver, and muscle but not in kidney or testis. |
| Top Pathways | Toxoplasmosis, TNF signaling pathway, MicroRNAs in cancer, Non-alcoholic fatty liver disease (NAFLD), Proteoglycans in cancer |
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