| Gene Symbol |
Casp3
|
| Entrez Gene |
25402
|
| Alt Symbol |
Lice
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
caspase 3
|
| Other Description |
CASP-3|CPP-32|CPP32beta|Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease)|Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease)|IRP|SCA-1|SREBP cleavage activity 1|apopain|caspase-3|cysteine protease CPP32|protein Yama|yama protein
|
| Swissprots |
Q62993 P70543 P97699 P55213
|
| Accessions |
EDL78892 EDL78893 EDL78894 P55213 BC081854 AAH81854 U34685 AAC52261 U49930 AAC52765 U84410 AAB41792 XM_006253130 XP_006253192 NM_012922 NP_037054
|
| Function |
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Expressed in heart, brain, liver, and muscle but not in kidney or testis.
|
| Top Pathways |
Toxoplasmosis, TNF signaling pathway, MicroRNAs in cancer, Non-alcoholic fatty liver disease (NAFLD), Proteoglycans in cancer
|