| Gene Symbol | BNIP3L |
|---|---|
| Entrez Gene | 665 |
| Alt Symbol | BNIP3a, NIX |
| Species | Human |
| Gene Type | protein-coding |
| Description | BCL2/adenovirus E1B 19kDa interacting protein 3-like |
| Other Description | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like|BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A|BCL2/adenovirus E1B 19-kd protein-interacting protein 3a|NIP3-like protein X|NIP3L|adenovirus E1B19k-binding protein B5 |
| Swissprots | B0AZS9 O60238 Q8NF87 Q5JW63 |
| Accessions | AAF70290 EAW63576 O60238 AA946755 AB004788 BAA28692 AF060922 AAG43134 AF067396 AAD03589 AF079221 AAC27723 AF452712 AAL50978 AF536326 AAN04051 AK290213 BAF82902 AK300286 BAG62043 AK300727 BAG62400 AK307195 AK315870 BAF98761 AK316315 BAH14686 AL132665 CAI46217 BC001559 AAH01559 BC009603 AAH09603 BF337139 BQ719112 BT019500 AAV38307 BT019501 AAV38308 CD244492 CD558918 CR456701 CAG32982 EU831983 ACE87424 EU832076 ACE86738 JF432628 ADZ15845 XM_005273617 XP_005273674 XM_011544630 XP_011542932 NM_004331 NP_004322 |
| Function | Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}. |
| Subcellular Location | Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Colocalizes with SPATA18 at the mitochondrion outer membrane. |