BNIP3L

Gene Symbol	BNIP3L
Entrez Gene	665
Alt Symbol	BNIP3a, NIX
Species	Human
Gene Type	protein-coding
Description	BCL2/adenovirus E1B 19kDa interacting protein 3-like
Other Description	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like|BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A|BCL2/adenovirus E1B 19-kd protein-interacting protein 3a|NIP3-like protein X|NIP3L|adenovirus E1B19k-binding protein B5
Swissprots	B0AZS9 O60238 Q8NF87 Q5JW63
Accessions	AAF70290 EAW63576 O60238 AA946755 AB004788 BAA28692 AF060922 AAG43134 AF067396 AAD03589 AF079221 AAC27723 AF452712 AAL50978 AF536326 AAN04051 AK290213 BAF82902 AK300286 BAG62043 AK300727 BAG62400 AK307195 AK315870 BAF98761 AK316315 BAH14686 AL132665 CAI46217 BC001559 AAH01559 BC009603 AAH09603 BF337139 BQ719112 BT019500 AAV38307 BT019501 AAV38308 CD244492 CD558918 CR456701 CAG32982 EU831983 ACE87424 EU832076 ACE86738 JF432628 ADZ15845 XM_005273617 XP_005273674 XM_011544630 XP_011542932 NM_004331 NP_004322
Function	Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}.
Subcellular Location	Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Colocalizes with SPATA18 at the mitochondrion outer membrane.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BNIP3L peptide - ab8431 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human BNIP3L protein fragment - ab114290 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

NIX / BNIP3L Antibody Blocking Peptide - LS-E1218 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NIX / BNIP3L Antibody Blocking Peptide - LS-E21546 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NIX / BNIP3L Antibody Blocking Peptide - LS-E29938 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human BNIP3L Protein - H00000665-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

BNIP3L Blocking Peptide - NBP1-77296PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

NIX-Antibody-Center-Blocking-peptide - BP11786c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human BNIP3L protein - orb84715 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source E. coli Species Human

Bnip3l Blocking Peptide - 33R-1671 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

BNIP3L / BNIP3A - H00000665-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BNIP3L / BNIP3A - H00000665-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Bnip3L Peptide - 2289P from ProSci Category Peptide Species Human

BNIP3L fusion protein - ag3624 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human BNIP3L - BNIP3L-26756TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human BNIP3L, None tagged - BNIP3L-6876H from Creative Biomart Category Protein Source E. coli Species Human

Human BNIP3L Protein - 12488-HNCE-20 from Sino Biological Category Protein Source E. coli Species Human

Recombinant Human BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like(BNIP3L) ,partial - CSB-YP002767HU CSB-EP002767HU CSB-BP002767HU CSB-MP002767HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Synthetic Human BNIP3L (aa 77-92)(IN) Blocking Peptide - PX051BP from Cell Science Category Peptide Prices $170.00 Sizes 50 μg Species Human

Recombinant Human BNIP3L Protein - PKSH030825 from Elabscience Category Protein Source E. coli Species Human

BNIP3L Protein - NBP1-88558PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

BNIP3L-BH3-Domain-Antibody-Blocking-Peptide - BP1320a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BNIP3L Peptide, Human - M34GP01489H from Creative Peptides Category Peptide Source Synthetic. Species Human

BNIP3L Recombinant Protein (OPCA02605) - OPCA02605 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Human BNIP3L Protein - 12488-HNCE from ABclonal Category Protein Prices $138.00, $348.00 Sizes 20 µg, 100 µg Source E. coli Species Human

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