BNIP3L

Gene Symbol BNIP3L
Entrez Gene 665
Alt Symbol BNIP3a, NIX
Species Human
Gene Type protein-coding
Description BCL2/adenovirus E1B 19kDa interacting protein 3-like
Other Description BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like|BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A|BCL2/adenovirus E1B 19-kd protein-interacting protein 3a|NIP3-like protein X|NIP3L|adenovirus E1B19k-binding protein B5
Swissprots B0AZS9 O60238 Q8NF87 Q5JW63
Accessions AAF70290 EAW63576 O60238 AA946755 AB004788 BAA28692 AF060922 AAG43134 AF067396 AAD03589 AF079221 AAC27723 AF452712 AAL50978 AF536326 AAN04051 AK290213 BAF82902 AK300286 BAG62043 AK300727 BAG62400 AK307195 AK315870 BAF98761 AK316315 BAH14686 AL132665 CAI46217 BC001559 AAH01559 BC009603 AAH09603 BF337139 BQ719112 BT019500 AAV38307 BT019501 AAV38308 CD244492 CD558918 CR456701 CAG32982 EU831983 ACE87424 EU832076 ACE86738 JF432628 ADZ15845 XM_005273617 XP_005273674 XM_011544630 XP_011542932 NM_004331 NP_004322
Function Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}.
Subcellular Location Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Colocalizes with SPATA18 at the mitochondrion outer membrane.

BNIP3L/Nix (D4R4B) Rabbit mAb - 12396 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4R4B
Western blot analysis of A172 and HeLa cells, untreated (-) or cobalt chloride-treated (100 μM, overnight; +), using BNIP3L/Nix (D4R4B) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

BNIP3L/Nix Antibody - 9089 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Nix (B-1) - sc-271076 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Nix (B-1): sc-271076. Western blot analysis of Nix expression in non-transfected: sc-117752 (A) and human Nix transfected: sc-113558 (B) 293T whole cell lysates.

Nix (C-15) - sc-5863 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Nix (C-15): sc-5863. Western blot analysis of Nix expression in non-transfected: sc-117752 (A) and human Nix transfected: sc-113558 (B) 293T whole cell lysates.

Nix (FL-219) - sc-28240 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Nix (FL-219): sc-28240. Western blot analysis of Nix expression in non-transfected: sc-117752 (A) and human Nix transfected: sc-113558 (B) 293T whole cell lysates.

Nix (N-19) - sc-5860 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Nix (N-19): sc-5860. Western blot analysis of Nix expression in non-transfected: sc-117752 (A) and human Nix transfected: sc-113558 (B) 293T whole cell lysates.

Anti-BNIP3L antibody - ab8399 from Abcam

Prices $400.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-BNIP3L antibody (ab8399) at 1 µg/mlLane 1 : K562 whole cell lysate with absence of immunogenic peptideLane 2 : K562 whole cell lysate with presence of immunogenic peptide

Anti-BNIP3L antibody - ab83808 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-BNIP3L antibody - ab53185 from Abcam

Prices $370.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-BNIP3L antibody [EPR4033] - ab109414 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4033
All lanes : Anti-BNIP3L antibody [EPR4033] (ab109414) at 1/1000 dilutionLane 1 : Raji cell lysateLane 2 : K562 cell lysateLysates/proteins at 10 µg per lane.

Anti-BNIP3L antibody, prediluted - ab53208 from Abcam

Prices $370.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal

Anti-BNIP3L antibody [ZN002] - ab54298 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone ZN002
Anti-BNIP3L antibody [ZN002] (ab54298) at 0.5 µg/ml + K562 cell lysates

Anti-NIX / BNIP3L Antibody - LS-C180158 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: BNIP3L Antibody - Analysis of BNIP3L in mouse prostate using DAB with hematoxylin counterstain.

Anti-NIX / BNIP3L Antibody - LS-C187895 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of human kidney with Rabbit anti-Human BNIP3L

Anti-NIX / BNIP3L Antibody (aa52-81) - LS-C164883 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
NIX Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human uterus tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-NIX / BNIP3L Antibody (aa77-92) IHC-plus™ - LS-B459 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-BNIP3L antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B459 concentration 5 ug/ml.

Anti-NIX / BNIP3L Antibody (aa77-92) - LS-C77115 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-NIX / BNIP3L Antibody (Internal) - LS-C50502 from LifeSpan Bioscience

Prices $530.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of Human Breast Carcinoma stained with anti-Bnip3L antibody

Anti-NIX / BNIP3L Antibody - LS-C153216 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NIX / BNIP3L Antibody - LS-C26612 from LifeSpan Bioscience

Prices $360.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of anti-Bnip3L (IN) antibody at 1 ug/ml on K562 whole cell lysate in the absence (1) and presence (2) of immunogenic peptide.

Anti-NIX / BNIP3L Antibody (DY650) - LS-C180833 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NIX / BNIP3L Antibody (Biotin) - LS-C180832 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NIX / BNIP3L Antibody (DY488) - LS-C180834 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NIX / BNIP3L Antibody (DY550) - LS-C180835 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NIX / BNIP3L Antibody (aa77-92) - LS-C188879 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
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