Ccnd2

Gene Symbol	Ccnd2
Entrez Gene	12444
Alt Symbol	2600016F06Rik, AI256817, BF642806, C86853, Vin-1, Vin1, cD2
Species	Mouse
Gene Type	protein-coding
Description	cyclin D2
Other Description	G1/S-specific cyclin-D2
Swissprots	P30280
Accessions	EDK99856 P30280 AK007904 BAB25338 AK009602 AK011225 AK011412 AK011429 AK077367 AK147345 BAE27858 AK160751 BAE35987 AK168954 BAE40760 AK182883 AK184705 AK185924 AK192301 AK193960 AK199582 AK202387 AK218587 BC049086 AAH49086 BY161742 CT010207 CAJ18415 M83749 AAA37519 M86182 AAA37503 XM_006505459 XP_006505522 XM_006505460 XP_006505523 NM_009829 NP_033959
Function	Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
Top Pathways	PI3K-Akt signaling pathway, Cell cycle, p53 signaling pathway, Focal adhesion, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

cyclin D2 (M-20) - sc-593 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Mouse-CCND2-Antibody-C-term-T279-T280 - AP20417b from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

CCND2 Antibody - C-terminal region (OAAB17943) - OAAB17943 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Cyclin D2 antibody (Thr280) - 70R-34500 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Cyclin D2 antibody - 70R-34501 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti -Cyclin D2 (CCND2) - 151699 from USBiological Life Science Host Rabbit Clonality Polyclonal

Anti -Cyclin D2 (CCND2) (AP) - 151699-AP from USBiological Life Science Host Rabbit Clonality Polyclonal

Anti -Cyclin D2 (CCND2) (APC) - 151699-APC from USBiological Life Science Host Rabbit Clonality Polyclonal

Anti -Cyclin D2 (CCND2) (Biotin) - 151699-Biotin from USBiological Life Science Host Rabbit Clonality Polyclonal

Anti -Cyclin D2 (CCND2) (FITC) - 151699-FITC from USBiological Life Science Host Rabbit Clonality Polyclonal

Anti -Cyclin D2 (CCND2) (HRP) - 151699-HRP from USBiological Life Science Host Rabbit Clonality Polyclonal

Anti -Cyclin D2 (CCND2) (PE) - 151699-PE from USBiological Life Science Host Rabbit Clonality Polyclonal

Cyclin D2 Antibody - abx100485 from Abbexa Host Rabbit Clonality Polyclonal

Mouse CCND2 Antibody - abx034759 from Abbexa Host Rabbit Clonality Polyclonal

Rabbit Anti-Mouse Mouse CCND2 (C-term T279/T280) - 102-14757 from RayBiotech Host Rabbit

Mouse Anti-Human Cyclin D2 - DS-MB-01078 from RayBiotech Host Mouse

CCND2 antibody (C-term) - STJ48189 from St John's Laboratory Ltd Host Rabbit Clonality Polyclonal Clone RB43028

CCND2, Polyclonal Antibody - MBS2519854 from MyBioSource Prices $195.00, $270.00, $435.00 Sizes 60 µl, 120 µl, 200 µl Host Rabbit Clonality Polyclonal

CCND2, Polyclonal Antibody - MBS6005304 from MyBioSource Prices $550.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

CCND2, Polyclonal Antibody - MBS2522195 from MyBioSource Prices $195.00, $270.00, $435.00 Sizes 60 µl, 120 µl, 200 µl Host Rabbit Clonality Polyclonal

CCND2, Polyclonal Antibody - MBS2518362 from MyBioSource Prices $110.00, $150.00, $225.00, $360.00 Sizes 20 µl, 60 µl, 120 µl, 200 µl Host Rabbit Clonality Polyclonal

CCND2, Polyclonal Antibody - MBS2526698 from MyBioSource Prices $110.00, $150.00, $225.00, $360.00 Sizes 20 µl, 60 µl, 120 µl, 200 µl Host Rabbit Clonality Polyclonal

Polyclonal Antibody to Cyclin D2 (CCND2) - PAA586Mu01 from Cloud-clone Host Rabbit Clonality Polyclonal

CCND2, Polyclonal Antibody - MBS9209879 from MyBioSource Prices $155.00, $340.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

Cyclin D2 Antibody (CCND2) (F52197) - F52197 from NSJ Bioreagent Prices $125.00, $299.00 Sizes 80 µl (In 1X PBS, pH 7.4, with 0.09% sodium azide), 400 µl (In 1X PBS, pH 7.4, with 0.09% sodium azide) Host Rabbit Clonality Polyclonal

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