| Gene Symbol | Ccnd2 |
|---|---|
| Entrez Gene | 12444 |
| Alt Symbol | 2600016F06Rik, AI256817, BF642806, C86853, Vin-1, Vin1, cD2 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | cyclin D2 |
| Other Description | G1/S-specific cyclin-D2 |
| Swissprots | P30280 |
| Accessions | EDK99856 P30280 AK007904 BAB25338 AK009602 AK011225 AK011412 AK011429 AK077367 AK147345 BAE27858 AK160751 BAE35987 AK168954 BAE40760 AK182883 AK184705 AK185924 AK192301 AK193960 AK199582 AK202387 AK218587 BC049086 AAH49086 BY161742 CT010207 CAJ18415 M83749 AAA37519 M86182 AAA37503 XM_006505459 XP_006505522 XM_006505460 XP_006505523 NM_009829 NP_033959 |
| Function | Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000250}. |
| Top Pathways | PI3K-Akt signaling pathway, Cell cycle, p53 signaling pathway, Focal adhesion, MicroRNAs in cancer |