Ccnd2

Gene Symbol	Ccnd2
Entrez Gene	12444
Alt Symbol	2600016F06Rik, AI256817, BF642806, C86853, Vin-1, Vin1, cD2
Species	Mouse
Gene Type	protein-coding
Description	cyclin D2
Other Description	G1/S-specific cyclin-D2
Swissprots	P30280
Accessions	EDK99856 P30280 AK007904 BAB25338 AK009602 AK011225 AK011412 AK011429 AK077367 AK147345 BAE27858 AK160751 BAE35987 AK168954 BAE40760 AK182883 AK184705 AK185924 AK192301 AK193960 AK199582 AK202387 AK218587 BC049086 AAH49086 BY161742 CT010207 CAJ18415 M83749 AAA37519 M86182 AAA37503 XM_006505459 XP_006505522 XM_006505460 XP_006505523 NM_009829 NP_033959
Function	Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
Top Pathways	PI3K-Akt signaling pathway, Cell cycle, p53 signaling pathway, Focal adhesion, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Mouse Cyclin D2 Protein - abx066199 from Abbexa Category Protein Source E.coli Species Mouse

Recombinant Cyclin D2 (CCND2) - RPA586Mu01 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Mouse G1/S-specific cyclin-D2(Ccnd2) - CSB-YP004812MO CSB-EP004812MO CSB-BP004812MO CSB-MP004812MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

Cyclin D2 (CCND2) - RPU141071 from Biomatik Category Protein Prices $261.80, $523.60, $785.40 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Mouse

Recombinant Mouse CCND2 Protein - CCND2-2989M from Creative Biomart Category Protein Source Mammalian Cells Species Mouse

Mouse-CCND2-Blocking-Peptide-C-term-T279T280 - BP20417b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg Species Mouse

G1/S-specific cyclin-D2 (Ccnd2), Recombinant Protein - MBS953629 from MyBioSource Category Protein Prices $1,045.00, $1,045.00, $1,275.00, $1,275.00, $1,625.00, $1,625.00, $2,085.00, $2,085.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Mouse

Recombinant Cyclin D2 (CCND2) - RPU41071 from Biomatik Category Protein Prices $209.00, $409.00, $655.00, $780.64 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Mouse

CCND2 Recombinant Protein (OPCD01973) - OPCD01973 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

Cyclin D2 (CCND2), Recombinant Protein - MBS2018503 from MyBioSource Category Protein Prices $195.00, $425.00, $660.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

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